A. Badrinarayanan

Exonuclease action of replicative polymerase gamma drives damage-induced mitochondrial DNA clearance

The paper investigates how mtDNA damage affects polymerase gamma activity and mtDNA stability in yeast, showing that exonuclease activity drives damage-induced mtDNA clearance.

Widespread prevalence of a post-translational modification in activation of an essential bacterial DNA damage response

The paper identifies a conserved bacterial transcription factor, Cada2, that mediates a methylation-dependent DNA damage response distinct from the SOS response.

Chromosome organization shapes replisome dynamics in Caulobacter crescentus

The paper tracks replisome dynamics in Caulobacter crescentus and finds that chromosome organization influences replisome colocalization and splitting, with replication-transcription conflicts affecting replication speed and replisome decoupling.

Requirement for specific bacterial genome maintenance pathways in repair of C8-linked pyrrolobenzodiazepine (PBD) bi-aryl monomer-mediated DNA damage

This study investigates how C8-linked PBD bi-aryl monomers cause DNA damage in Caulobacter crescentus and identifies the repair mechanisms required for survival.

Dynamic reorganization and selective segregation of mitochondria under DarT-mediated mtDNA damage

The paper induces mtDNA damage using DarT and shows that mitochondrial reorganization occurs independently of mtDNA loss and mitophagy.

SMC protein RecN drives RecA filament translocation and remodelling for in vivo homology search

This study identifies RecN as essential for RecA filament translocation and remodelling during homology search in Caulobacter, revealing a novel search strategy involving directional movement and dynamic filament changes.

A CTP-dependent gating mechanism enables ParB spreading on DNA

This study identifies a CTP-dependent gating mechanism in ParB that regulates its nucleation, spreading, and recycling during chromosome segregation in Caulobacter crescentus.

Coordination between nucleotide excision repair and specialized polymerase DnaE2 action enables DNA damage survival in non-replicating bacteria

The paper shows that DnaE2, a specialized polymerase, works with nucleotide excision repair (NER) in non-replicating bacteria to repair DNA damage and restore the cell cycle.

Asymmetric chromosome segregation and cell division in DNA damage-induced bacterial filaments

This study shows that DNA damage in E. coli leads to filamentation, which is resolved by asymmetric division producing wild-type sized daughter cells.