Author

O. Gorka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:long-read sequencing· 1 Approach:statistical model· 1

Frequent Co-Authors

O. Gross· 2 shared A. Boettcher· 1 shared A. F. Arenas Soto· 1 shared A. Kostina· 1 shared A. M. Bastidas Quintero· 1 shared B. S. Saller· 1 shared B. Saller· 1 shared C. Agarinis· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

O. Gross

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Dual role of Toxoplasma gondii ROP5 and ROP18 for NLRP3 inhibition

M. Murillo-Leon, A. M. Bastidas Quintero, S. Singh, X. Mueller, O. Gorka, B. Saller, A. F. Arenas Soto, C. Campos, J. E. Gomez-Marin, O. Gross, K. Pfeffer, J. C. Howard, G. A. Taylor, T. Steinfeldt

This paper identifies vacuolar disruption as a trigger for NLRP3 inflammasome activation in Toxoplasma gondii infection and shows ROP5 and ROP18 inhibit IL-1β release by protecting the parasitophorous vacuole and interacting with GBP5.

bioRxiv · Sep 17, 2023 · PreprintMicrobiology

T helper cells exhibit a dynamic and reversible 3'UTR landscape.

D. Seyres, O. Gorka, R. Schmidt, R. Marone, M. Zavolan, L. T. Jeker

The paper examines 3'UTR dynamics in T helper cells, finding that alternative polyadenylation (APA) events are transient and do not strongly correlate with differential gene expression.

bioRxiv · Jan 19, 2023Immunology

Tyrosine kinase inhibitors trigger lysosomal damage-associated cell lysis to activate the NLRP3 inflammasome

E. Neuwirt, G. Magnani, T. Cikovic, A. Kostina, S. Wohrle, S. Flemming, N. J. Fischenich, B. S. Saller, O. Gorka, S. Renner, C. Agarinis, C. Parker, A. Boettcher, C. J. Farady, R. Backofen, , O. Gross

A small molecule screen identifies tyrosine kinase inhibitors that cause lysosomal damage, leading to cell lysis and NLRP3 inflammasome activation via K+ efflux.

bioRxiv · Feb 19, 2022 · PreprintImmunology