Author

O. Gross

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

B. S. Saller· 2 shared O. Gorka· 2 shared A. Boettcher· 1 shared A. F. Arenas Soto· 1 shared A. Kostina· 1 shared A. M. Bastidas Quintero· 1 shared A.-K. Classen· 1 shared B. Saller· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

B. S. Saller

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dual role of Toxoplasma gondii ROP5 and ROP18 for NLRP3 inhibition

M. Murillo-Leon, A. M. Bastidas Quintero, S. Singh, X. Mueller, O. Gorka, B. Saller, A. F. Arenas Soto, C. Campos, J. E. Gomez-Marin, O. Gross, K. Pfeffer, J. C. Howard, G. A. Taylor, T. Steinfeldt

This paper identifies vacuolar disruption as a trigger for NLRP3 inflammasome activation in Toxoplasma gondii infection and shows ROP5 and ROP18 inhibit IL-1β release by protecting the parasitophorous vacuole and interacting with GBP5.

bioRxiv · Sep 17, 2023 · PreprintMicrobiology

Sequentially activated death complexes regulate pyroptosis and IL-1β release in response to Yersinia blockade of immune signaling

R. S. Wertman, C. K. Go, B. S. Saller, O. Gross, P. Scott, I. E. Brodsky

This study shows that Yersinia-induced cell death and IL-1β release are driven by spatially and temporally distinct but functionally connected death complexes.

bioRxiv · Sep 14, 2023 · PreprintImmunology

DNA damage signaling in Drosophila macrophages modulates systemic cytokine levels in response 1 to oxidative stress

F. Hersperger, T. Meyring, P. Weber, C. Chhatbar, G. Monaco, M. S. Dionne, K. Paeschke, M. Prinz, O. Gross, A.-K. Classen, K. Kierdorf

This study identifies DNA damage signaling in Drosophila macrophages as a key regulator of cytokine release and oxidative stress response through JNK and unpaired-3.

bioRxiv · Feb 22, 2023 · PreprintImmunology

Tyrosine kinase inhibitors trigger lysosomal damage-associated cell lysis to activate the NLRP3 inflammasome

E. Neuwirt, G. Magnani, T. Cikovic, A. Kostina, S. Wohrle, S. Flemming, N. J. Fischenich, B. S. Saller, O. Gorka, S. Renner, C. Agarinis, C. Parker, A. Boettcher, C. J. Farady, R. Backofen, , O. Gross

A small molecule screen identifies tyrosine kinase inhibitors that cause lysosomal damage, leading to cell lysis and NLRP3 inflammasome activation via K+ efflux.

bioRxiv · Feb 19, 2022 · PreprintImmunology