Author

A. Kostina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:development & morphogenesis· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Assay:metabolomics· 1 Assay:organoid / primary culture· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

A. Aguirre· 2 shared A. Huang· 2 shared A. Wasserman· 2 shared B. Volmert· 2 shared Y. Lewis-Israeli· 2 shared A. Boettcher· 1 shared A. Juhong· 1 shared A. Kiselev· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBioengineering

A. Aguirre

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ER stress and lipid imbalance drive embryonic cardiomyopathy in a human heart organoid model of pregestational diabetes

A. Kostina, Y. Lewis-Israeli, M. Abdelhamid, M. Gabalski, B. Volmert, H. Lankerd, A. Huang, A. Wasserman, T. Lydic, C. Chan, I. Olomu, A. Aguirre

This study uses human heart organoids to show that pregestational diabetes causes ER stress and lipid imbalance, leading to cardiomyopathy, and identifies potential therapeutic targets.

bioRxiv · Jun 7, 2023 · PreprintBioengineering

A patterned human heart tube organoid model generated by pluripotent stem cell self-assembly

B. Volmert, A. Riggs, F. Wang, A. Juhong, A. Kiselev, A. Kostina, C. O'Hern, P. Muniyandi, A. Wasserman, A. Huang, Y. Lewis-Israeli, S. Park, Z. Qiu, C. Zhou, A. Aguirre

This paper develops a patterned human heart tube organoid model using pluripotent stem cell self-assembly, showing anterior-posterior patterning and multiple cardiac cell types.

bioRxiv · Dec 16, 2022 · PreprintBioengineering

Tyrosine kinase inhibitors trigger lysosomal damage-associated cell lysis to activate the NLRP3 inflammasome

E. Neuwirt, G. Magnani, T. Cikovic, A. Kostina, S. Wohrle, S. Flemming, N. J. Fischenich, B. S. Saller, O. Gorka, S. Renner, C. Agarinis, C. Parker, A. Boettcher, C. J. Farady, R. Backofen, , O. Gross

A small molecule screen identifies tyrosine kinase inhibitors that cause lysosomal damage, leading to cell lysis and NLRP3 inflammasome activation via K+ efflux.

bioRxiv · Feb 19, 2022 · PreprintImmunology