Inhibitory IL-10-producing CD4+ T cells develop in a T-bet-dependent manner and facilitate cytomegalovirus persistence via coexpression of arginase-1
M. Clement, K. Ladell, K. L. Miners, M. Marsden, L. Chapman, A. Cardus-Figueras, J. Scott, R. Andrews, S. Clare, V. V. Kriukova, K. R. Lupyr, O. V. Britanova, D. R. Withers, D. M. Chudakov, S. A. Jones, , I. Humphreys
The paper identifies IL-10-producing CD4+ T cells that develop via T-bet dependence and Arg1 coexpression, promoting cytomegalovirus persistence.
bioRxiv · Jan 25, 2022Immunology