Author

I. Humphreys

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

B. Jin· 2 shared D. Wellington· 2 shared J. L. Forbester· 2 shared M. Clement· 2 shared M. Marsden· 2 shared S. Clare· 2 shared S. Makvandi-Nejad· 2 shared T. Dong· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

B. Jin

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Author profile →

4 papers

Recent·Most cited

Efficient and accurate prediction of protein structure using RoseTTAFold2

M. Baek, I. Anishchenko, I. Humphreys, Q. Cong, D. Baker, F. DiMaio

This paper introduces RoseTTAFold2, a protein structure prediction method that achieves AlphaFold2-level accuracy without using its key features, demonstrating the potential for diverse model architectures.

bioRxiv · May 24, 2023 · PreprintBiochemistry

Inhibitory IL-10-producing CD4+ T cells develop in a T-bet-dependent manner and facilitate cytomegalovirus persistence via coexpression of arginase-1

M. Clement, K. Ladell, K. L. Miners, M. Marsden, L. Chapman, A. Cardus-Figueras, J. Scott, R. Andrews, S. Clare, V. V. Kriukova, K. R. Lupyr, O. V. Britanova, D. R. Withers, D. M. Chudakov, S. A. Jones, , I. Humphreys

The paper identifies IL-10-producing CD4+ T cells that develop via T-bet dependence and Arg1 coexpression, promoting cytomegalovirus persistence.

bioRxiv · Jan 25, 2022Immunology

IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses

M. Clement, J. L. Forbester, M. Marsden, P. Sabberwal, D. Wellington, S. Dimonte, K. Harcourt, S. Clare, Z. Yin, L. Nobre, R. Antrobus, B. Jin, M. Chen, S. Makvandi-Nejad, J. A. Lindborg, , I. Humphreys

This study shows IFITM3 limits viral pathogenesis by regulating Nogo-B-mediated TLR responses and cytokine production in dendritic cells.

bioRxiv · Jul 23, 2021 · PreprintImmunology

Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infection

D. Wellington, Z. Yin, L. Zhang, J. L. Forbester, K. Kite, H. Laurenson-Schafer, S. Makvandi-Nejad, B. Jin, E. Bowes, K. Manoharan, D. Maldonado-Perez, C. Verrill, I. Humphreys, T. Dong

This study shows that low basal expression and slow induction of IFITM3 in immune cells increases their susceptibility to influenza A virus infection.

bioRxiv · Dec 20, 2019 · PreprintImmunology