Author

D. R. Withers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 6 Research Focus:cell type annotation· 5 Assay:bulk RNA-seq· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Assay:scRNA-seq· 2

Frequent Co-Authors

I. Dean· 3 shared B. C. Kennedy· 2 shared C. Willis· 2 shared C. Y. Lee· 2 shared D. Sosnowska· 2 shared F. Gaspal· 2 shared G. Carlesso· 2 shared J. Caron· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

I. Dean

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Rapid establishment of a tumor-retained state curtails the contribution of conventional NK cells to anti-tumor immunity in solid cancers

I. W. Dean, C. Y. Lee, Z. K. Tuong, Z. Li, C. A. Tibbitt, C. Willis, F. Gaspal, B. C. Kennedy, V. Matei-Rascu, R. Fiancette, C. Nordenvall, U. Lindforss, S. M. Baker, C. Stockmann, V. Sexl, , D. R. Withers

This study shows that conventional NK cells rapidly lose effector functions upon entering tumors and that IL-15:IL-15Ra complexes can restore their function and tissue-residency.

bioRxiv · Aug 10, 2023Immunology

Time-, tissue- and treatment-associated heterogeneity in tumour-residing migratory DCs

C. Y. Lee, B. C. Kennedy, N. Richoz, I. Dean, Z. K. Tuong, F. Gaspal, Z. Li, C. Willis, T. Hasegawa, S. K. Whiteside, D. A. Posner, G. Carlesso, S. A. Hammond, S. Dovedi, R. Roychoudhuri, , M. R. Clatworthy

This study identifies heterogeneous tumor-residing migratory dendritic cells (mRegDCs) that show distinct transcriptional and functional profiles, impacting anti-tumor immune responses.

bioRxiv · Jul 3, 2023Immunology

ILC3s select for RORγt+ Tregs and establish tolerance to intestinal microbiota

M. Lyu, H. Suzuki, L. Kang, F. F. Gaspal, W. Zhou, J. Goc, L. Zhou, J. Z. Zhou, W. Zhang, J. Live Cell Bank, Z. Shen, J. G. Fox, R. Sockolow, T. M. Laufer, Y. Fan, , G. F. Sonnenberg

This study identifies ILC3s as key regulators that promote RORγt+ Tregs and suppress Th17 cells to maintain intestinal tolerance to microbiota.

bioRxiv · Apr 25, 2022Immunology

Perivascular macrophages collaborate to facilitate chemotherapy resistance in cancer

J. E. Anstee, J. W. Opzoomer, I. Dean, H. P. Muller, M. Bahri, K. Liakath-Ali, Z. Liu, D. Choy, J. Caron, D. Sosnowska, R. Beatson, T. Muliaditan, Z. An, C. E. Gillett, G. Lan, , J. N. Arnold

This study identifies Lyve-1+ perivascular macrophages that form nests and contribute to chemotherapy resistance by excluding CD8+ T-cells and relying on IL-6 and CCR5/CCL3/4 signaling.

bioRxiv · Feb 3, 2022Cancer Biology

Inhibitory IL-10-producing CD4+ T cells develop in a T-bet-dependent manner and facilitate cytomegalovirus persistence via coexpression of arginase-1

M. Clement, K. Ladell, K. L. Miners, M. Marsden, L. Chapman, A. Cardus-Figueras, J. Scott, R. Andrews, S. Clare, V. V. Kriukova, K. R. Lupyr, O. V. Britanova, D. R. Withers, D. M. Chudakov, S. A. Jones, , I. Humphreys

The paper identifies IL-10-producing CD4+ T cells that develop via T-bet dependence and Arg1 coexpression, promoting cytomegalovirus persistence.

bioRxiv · Jan 25, 2022Immunology

Macrophages orchestrate the expansion of a pro-angiogenic perivascular niche during cancer progression

J. W. Opzoomer, J. E. Anstee, I. Dean, E. J. Hill, I. Bouybayoune, J. Caron, T. Muliaditan, P. Gordon, D. Sosnowska, R. Nuamah, S. E. Pinder, T. Ng, F. Dazzi, S. Kordasti, D. R. Withers, , J. N. Arnold

This study identifies Lyve-1+ tumor-associated macrophages that support tumor growth by maintaining a pro-angiogenic perivascular niche through platelet-derived growth factor-CC-dependent expansion of mesenchymal cells.

bioRxiv · Oct 30, 2020Cancer Biology