Author

I. Saha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

S. Saffarian· 4 shared A. Petersen· 2 shared B. MacArthur· 2 shared B. Preece· 2 shared F.-U. Hartl· 2 shared H. Durden· 2 shared R. Gallegos· 2 shared W. Baumeister· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBiophysics

S. Saffarian

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Author profile →

7 papers

Recent·Most cited

Competitive assembly resolves the stoichiometry of essential proteins in infectious HIV-1 virions.

H. Durden, B. Preece, R. Gallegos, I. Saha, B. MacArthur, A. Petersen, W. Peppel, S. Saffarian

The paper measures the stoichiometry of Gag-Pol and gp120/gp41 proteins in infectious HIV-1 virions using a competitive assembly method, finding it similar to all released virions.

bioRxiv · Mar 10, 2024 · PreprintBiophysics

Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes

A. S. Chawla, H. J. Watt, S. A. Schattgen, N. Skariah, I. Saha, K. Warrick, M. Ogawa, F. Lamoliatte, J. Strid, A. Copland, S. Pryde, E. Knatko, K. D. Rasmussen, K. Kikuchi, P. G. Thomas, , M. Swamy

The paper identifies a conserved mechanism, RePrESS, by which autoreactive innate-like T cells maintain tolerance through rewiring of the TCR signalosome.

bioRxiv · Sep 1, 2023 · PreprintImmunology

Autophagy preferentially degrades non-fibrillar polyQ aggregates

D. Y. Zhao, F. J. Bauerlein, I. Saha, F.-U. Hartl, W. Baumeister, F. Wilfling

This study shows autophagosomes preferentially degrade non-fibrillar polyQ aggregates by interacting with p62, while amyloid fibrils evade clearance due to their non-deformable structure.

bioRxiv · Aug 8, 2023Cell Biology

Defects in the HIV immature lattice support essential lattice remodeling within budded virions

S.-K. Guo, I. Saha, S. Saffarian, M. E. Johnson

This paper uses reaction-diffusion simulations to show that incomplete HIV immature lattice dynamics enable rapid Gag-Pol dimerization, essential for viral maturation.

bioRxiv · Nov 21, 2022Biophysics

Competitive HIV budding suggests that a self-packaging gRNA:Gag-Pol complex directs HIV assembly and enforces infectivity.

H. Durden, I. Saha, B. Preece, B. MacArthur, A. Petersen, W. Peppel, R. Gallegos, S. Saffarian

The paper investigates HIV assembly by testing infectious/non-infectious genome mixtures, finding that a gRNA:Gag-Pol complex drives virion formation and infectivity.

bioRxiv · Aug 3, 2022 · PreprintMicrobiology

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds

I. Saha, P. Yuste-Checa, M. da Silva Padilha, Q. Guo, R. Körner, H. Holthusen, V. A. Trinkaus, I. Dudanova, R. Fernandez-Busnadiego, W. Baumeister, D. W. Sanders, S. Gautam, M. I. Diamond, F.-U. Hartl, M. S. Hipp

This study shows that the AAA+ chaperone VCP disaggregates Tau fibrils and generates seeding-active Tau as a byproduct, suggesting a role in aggregate removal and spreading in tauopathies.

bioRxiv · Feb 18, 2022Cell Biology

Interferometric Fluorescent Cross Correlation Spectroscopy

I. Saha, S. Saffarian

The paper introduces a method to measure fluorescent molecule transport in aqueous samples using single photon interference and FCS, achieving high-resolution measurements in thousands of voxels.

bioRxiv · Jun 13, 2019Biophysics