Author

C. Shema Mugisha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. B. Kutluay· 3 shared H. R. Vuong· 2 shared J. E. Eschbach· 2 shared K. Davis· 2 shared K. Tenneti· 2 shared M. Puray-Chavez· 2 shared A. A. Kennedy· 1 shared A. E. Hargrove· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

S. B. Kutluay

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Emergence of compensatory mutations reveal the importance of electrostatic interactions between HIV-1 integrase and genomic RNA

C. Shema Mugisha, T. Dinh, A. Kumar, K. Tenneti, J. E. Eschbach, K. Davis, R. Gifford, M. Kvaratskhelia, S. Kutluay

This study identifies compensatory mutations that restore HIV-1 integrase-gRNA binding and infectivity, revealing the role of electrostatic interactions in this process and their impact on allosteric inhibitor sensitivity.

bioRxiv · Dec 16, 2021Microbiology

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

M. Puray-Chavez, K. M. Lapak, T. P. Schrank, J. L. Elliott, D. P. Bhatt, M. J. Agajanian, R. Jasuja, D. Q. Lawson, K. Davis, P. W. Rothlauf, H. Jo, N. Lee, K. Tenneti, J. E. Eschbach, C. Shema Mugisha, , S. B. Kutluay

This study identifies H522 cells as ACE2-negative human cells permissive to SARS-CoV-2 infection, revealing alternative receptor usage and host response mechanisms.

bioRxiv · Mar 1, 2021Microbiology

Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures

M. Zafferani, C. Haddad, L. Luo, J. Davila-Calderon, L. Yuan-Chiu, C. Shema Mugisha, A. G. Monaghan, A. A. Kennedy, J. D. Yesselman, R. R. Gifford, A. W. Tai, S. B. Kutluay, M.-L. Li, G. Brewer, B. S. Tolbert, A. E. Hargrove

This study identifies amilorides as small molecules that inhibit SARS-CoV-2 replication by targeting conserved RNA structures in the 5-UTR region.

bioRxiv · Dec 5, 2020Microbiology

A facile Q-RT-PCR assay for monitoring SARS-CoV-2 growth in cell culture

C. Shema Mugisha, H. R. Vuong, M. Puray-Chavez, S. B. Kutluay

This paper develops a Q-RT-PCR assay to monitor SARS-CoV-2 growth in cell culture without RNA extraction, showing it can identify inhibitors of viral replication.

bioRxiv · Jun 26, 2020 · PreprintMicrobiology