G. Altan-Bonnet

Apoptotic contraction drives target cell release by cytotoxic T cells

This study identifies apoptotic contraction as a mechanism driving CTL dissociation and target cell release.

T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling

This study shows that TCR and IL-2 signaling strength during vaccination epigenetically programs memory CD8+ T cell functional fitness through chromatin remodeling.

Quantitative Immunology for Physicists

This paper reviews recent theoretical and experimental contributions from physicists to quantitative immunology, focusing on methodologies to predict immune system behavior.

TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors

This study shows that TGFβ inhibits IFNα/β production and tumor rejection in spontaneous mammary tumors, and blocking TGFβ enhances DMXAA-induced tumor regression.

Quantifying the dynamics of hematopoiesis by in vivo IdU pulse-chase, mass cytometry and mathematical modeling

The paper develops a method combining IdU pulse-chase, mass cytometry, and mathematical modeling to quantify hematopoietic differentiation dynamics in mice.

Modeling of cytometry data in logarithmic space: when is a bimodal distribution not bimodal?

The paper shows that bimodal distributions in logarithmic cytometry data may reflect unimodal distributions in linear scale and introduces a test to detect this mismatch.