Author

A. Gorelik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

E. W. Tate· 2 shared A. Argoetti· 1 shared A. Goya Grocin· 1 shared A. Kshirsagar· 1 shared A. Palmigiano· 1 shared A. S. Bell· 1 shared A. T. Ferenbach· 1 shared A. V. Pshezhetsky· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

E. W. Tate

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins

T. Xu, R. Heon-Roberts, T. Moore, P. Dubot, X. Pan, T. Guo, C. W. Cairo, R. Holley, B. Bigger, T. Durcan, T. Levade, J. Ausseil, B. Amilhon, A. Gorelik, B. Nagar, , A. V. Pshezhetsky

This study shows that reduced NEU1 activity in neurological MPS leads to hypersialylation of brain glycoproteins, contributing to CNS pathology through disrupted synaptogenesis and behavior.

bioRxiv · Apr 26, 2024 · PreprintBiochemistry

LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways

A. Kshirsagar, A. Gorelik, T. Olender, T. Sapir, D. Tsuboi, I. Rosenhek-Goldian, S. Malitsky, M. Itkin, A. Argoetti, Y. Mandel-Gutfreund, S. R. Cohen, J. H. Hanna, I. Ulitsky, K. Kaibuchi, O. Reiner

This study shows LIS1 regulates mESCs viability and mechanosensitive properties through RNA-binding interactions with AGO2 and other proteins.

bioRxiv · Mar 8, 2022Cell Biology

Discovery of lipid-mediated protein-protein interactions in living cells using metabolic labeling with photoactivatable clickable probes

R. O. Fedoryshchak, A. Gorelik, M. Shen, M. M. Shchepinova, I. Perez-Dorado, E. W. Tate

The paper develops lipid PTM-specific probes to capture protein-protein interactions in living cells, identifying novel interactors of myristoylated proteins.

bioRxiv · Dec 15, 2021Biochemistry

N-myristoyltransferase inhibition is synthetic lethal in MYC-deregulated cancers

G. A. Lueg, M. Faronato, A. Gorelik, A. Goya Grocin, E. Caamano-Gutierrez, F. Falciani, R. Solari, R. Carr, A. S. Bell, E. Bartlett, J. A. Hutton, M. Llorian-Sopena, P. Chakravarty, B. Brzezicha, M. Janz, , E. W. Tate

N-myristoyltransferase inhibition causes mitochondrial dysfunction and cell death in MYC-deregulated cancers through post-transcriptional failure in complex I synthesis.

bioRxiv · Mar 20, 2021 · PreprintCancer Biology

CRISPR-Cas9-mediated depletion of O-GlcNAc hydrolase and transferase for functional dissection of O-GlcNAcylation in human cells

A. Gorelik, A. T. Ferenbach

This study uses CRISPR-Cas9 to deplete OGT and OGA in human cells, revealing compensatory changes in enzyme expression and O-GlcNAcylation levels.

bioRxiv · Aug 19, 2020 · PreprintBiochemistry