Author

S. Connolly

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Gulsevin· 3 shared A. K. Kenworthy· 3 shared B. Han· 3 shared E. Karakas· 3 shared J. Meiler· 3 shared M. D. Ohi· 3 shared H. Mchaourab· 2 shared Y. Peskova· 2 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiophysics

A. Gulsevin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Evolutionarily diverse caveolins share a common structural framework built around amphipathic discs

B. Han, S. Connolly, L. F. L. Wilson, D. T. Schultz, A. Gulsevin, J. Meiler, E. Karakas, M. D. Ohi, A. K. Kenworthy

The paper predicts structures for 73 caveolins across animal diversity and identifies conserved structural elements and amphipathic disc assembly, revealing an ancient structural framework predating Metazoa.

bioRxiv · Nov 15, 2022Biophysics

Structural characterization of a breast cancer-associated mutation in caveolin-1

B. Han, A. Gulsevin, S. Connolly, T. Wang, J. Porta, A. Tiwari, A. Deng, L. Chang, Y. Peskova, H. Mchaourab, E. Karakas, M. D. Ohi, J. Meiler, A. K. Kenworthy

This study examines how a breast cancer-associated mutation in CAV1, P132L, affects its structure and oligomerization, revealing its impact on caveolae formation.

bioRxiv · May 23, 2022 · PreprintBiophysics

Molecular architecture of the human caveolin-1 complex

J. C. Porta, B. Han, A. Gulsevin, J. Chung, Y. Peskova, S. Connolly, H. Mchaourab, J. Meiler, E. Karakas, A. K. Kenworthy, M. D. Ohi

The paper uses cryo-electron microscopy to reveal the structure of the human caveolin-1 complex, showing it forms a disc with a flat membrane-binding surface.

bioRxiv · Feb 17, 2022Biophysics

Carbonyl Post-Translational Modification Associated with Early Onset Type 1 Diabetes Autoimmunity

M.-L. Yang, S. Connolly, R. Gee, T. Lam, J. Kanyo, S. G. Clarke, C. F. Clarke, E. A. James, C. Speake, C. Evans-Molina, L. Wen, K. C. Herold, M. Mamula

The paper identifies carbonylated P4Hb as an autoantigen in type 1 diabetes, detected before hyperglycemia in NOD mice and early human disease.

bioRxiv · Jun 15, 2021 · PreprintImmunology