J. Chung

Utility of Cellular Measurements of Non-Specific Endocytosis to Assess the Target-Independent Clearance of Monoclonal Antibodies

The paper develops a cell-based assay to measure non-specific endocytosis of monoclonal antibodies and shows that high non-specific uptake correlates with target-independent clearance and low bioavailability.

Stereotypic persistent B cell receptor clonotypes in Alzheimer's Disease

The paper identifies stereotypic BCR clonotypes in Alzheimer's Disease patients that persist over time and are not found in healthy controls, suggesting potential diagnostic signatures.

An ancestral vaccine induces anti-Omicron antibodies by hypermutation

This study shows that repeated mRNA vaccination leads to BCR hypermutation, enabling antibodies to neutralize Omicron variants.

Pore-like diffusion barriers in murine cardiac myocytes

The paper measures solute diffusion in cardiac myocytes and finds that diffusion is significantly restricted, likely due to myofilament and mitochondrial networks, with porin channels allowing faster diffusion.

Novel porcine model reveals two distinct LGR5 cell types during lung development and homeostasis

The paper identifies two distinct LGR5+ cell types in the lung using a novel porcine model, showing conservation in humans but not mice.

Molecular architecture of the human caveolin-1 complex

The paper uses cryo-electron microscopy to reveal the structure of the human caveolin-1 complex, showing it forms a disc with a flat membrane-binding surface.

Sex-specific distribution and classification of Wolbachia infections and mitochondrial DNA haplogroups in Aedes albopictus from the Indo-Pacific

The paper analyzes genomic data from Aedes albopictus across the Indo-Pacific to classify Wolbachia infections and mitochondrial haplogroups, finding sex-specific infection patterns and no cryptic species.

Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane

This study investigates how seipin's transmembrane segments contribute to triglyceride nucleation and lipid droplet budding using simulations and cell experiments.

An open-access volume electron microscopy atlas of whole cells and tissues

The paper presents a 3D electron microscopy atlas of whole cells and tissues with high resolution and large volume, enabling new biological insights.

Development of a machine learning model to estimate biotic ligand model-based predicted no-effect concentrations for copper in freshwater

The paper develops DNN models to estimate BLM-based PNECs for copper in freshwater using different input variables, showing improved predictive performance compared to existing tools.

The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets

This study identifies spartin as a receptor mediating selective autophagy of lipid droplets and links its dysfunction to Troyer syndrome.

Genetic stability of Aedes aegypti populations following invasion by wMel Wolbachia

This study examines genetic stability in Aedes aegypti populations after Wolbachia wMel introduction, finding genome-wide stability but some gene-level changes related to immune response and development.

Volatiles from Serratia marcescens, S. proteamaculans, and Bacillus subtilis Inhibit Growth of Rhizopus stolonifer and Other Fungi

This paper identifies volatile compounds from three bacteria that inhibit fungal growth and develops a pipeline to translate these profiles into candidate antifungal compounds.

IP3R activity increases frequency of RyR-mediated sparks by elevating dyadic Ca2+

The paper develops a mathematical model to show IP3R activity increases Ca2+ sparks by raising dyadic Ca2+ levels, which sensitizes RyRs but reduces JSR Ca2+ availability.

Stereotypic Neutralizing VH Clonotypes Against SARS-CoV-2 RBD in COVID-19 Patients and the Healthy Population

The paper identifies stereotypic VH clonotypes against SARS-CoV-2 RBD in patients and healthy individuals, showing their pre-existing presence in the healthy population.

Heterogeneous genetic invasions of three insecticide resistance mutations in Indo-Pacific populations of Aedes aegypti (L.)

The paper investigates the genetic spread of pyrethroid resistance mutations in Aedes aegypti across the Indo-Pacific, finding that resistance allele combinations spread through linked selection rather than dispersal.

Injectable therapeutic organoids using sacrificial hydrogels

This paper introduces a method using sacrificial hydrogels to produce reproducible multicellular organoid structures for cell therapy, demonstrating their ability to form functional vasculature in vivo.

Acquired FGFR and FGF alterations confer resistance to estrogen receptor (ER) targeted therapy in ER+ metastatic breast cancer

This study identifies FGFR and FGF pathway alterations as acquired resistance mechanisms to ER-targeted therapy in ER+ metastatic breast cancer and suggests targeted inhibitors as potential treatments.

Vaccination with single plasmid DNA encoding IL-12 and antigens of severe fever with thrombocytopenia syndrome virus elicits complete protection in IFNAR knockout mice

This paper develops a DNA vaccine encoding SFTSV antigens and adjuvants that provides complete protection in IFNAR knockout mice, while protein antigens alone fail to do so.

Nanoscale subcellular architecture revealed by multicolor 3D salvaged fluorescence imaging

This paper introduces a super-resolution microscope that images whole mammalian cells at ~20 nm 3D resolution, revealing complex cellular structures previously only visible via electron microscopy.

An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus

This paper isolates an antibody from a recovered SFTS patient that inhibits multiple SFTSV strains and protects mice from infection, suggesting its potential as a therapeutic agent.

High-throughput retrieval of physical DNA for NGS-identifiable clones in phage display library

The paper introduces a high-throughput platform, TrueRepertoire, for accurate clone identification and retrieval in phage display libraries, validated on a human hepatocyte growth factor-targeting scFv library.

Maximum likelihood estimation of fitness components in experimental evolution

The paper develops a maximum likelihood framework to estimate fitness components in experimental evolution using Drosophila melanogaster data, finding reduced mating preference and viability for a yellow allele.