Author

S. Byrum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Storey· 2 shared A. Tackett· 2 shared G. G. Wang· 2 shared L. Cai· 2 shared R. Edmondson· 2 shared S. Mackintosh· 2 shared W. Gong· 2 shared Y.-H. Tsai· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiochemistry

A. Storey

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy

X. Zhang, R. D. Pechous, P. A. Malaviarachchi, S. K. Banerjee, S. Byrum, D. Alkam, A. Ghaffarieh, R. C. Kurten, J. L. Kennedy

This paper establishes an ex vivo human precision-cut lung slice platform to study SARS-CoV-2 infection, immune responses, and drug efficacy, identifying key cytokines and viral RNA persistence as important features of COVID-19.

bioRxiv · Apr 18, 2023 · PreprintMicrobiology

A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing

H. Fan, Y. Guo, Y.-H. Tsai, A. Storey, A. Kim, W. Gong, R. Edmondson, S. Mackintosh, H. Li, S. Byrum, A. Tackett, L. Cai, G. G. Wang

This paper identifies a conserved BAH module in BAHD1 that reads H3K27me3 and mediates gene silencing by recruiting histone deacetylases, essential for development.

bioRxiv · Mar 11, 2021Biochemistry

YY1 cistrome analysis uncovers an essential requirement of the YY1:BRD4-PFKP regulatory axis for promoting tumorigenesis of castration-resistant prostate cancer

L. Cai, C. Xu, Y.-H. Tsai, P. Galbo, W. Gong, A. Storey, Y. Xu, S. Byrum, Y. Whang, J. Parker, S. Mackintosh, R. Edmondson, A. Tackett, J. Huang, D. Zheng, , G. G. Wang

This study identifies a YY1:BRD4-PFKP regulatory axis critical for castration-resistant prostate cancer tumorigenesis through cistrome analysis and functional experiments.

bioRxiv · Sep 17, 2020 · PreprintCancer Biology

Methionine stress induces a ferroptotic gene signature in methionine dependent cancer cells

K. F. Wallis, J. T. Bird, A. J. Gies, S. G. Mackintosh, A. J. Tackett, S. Byrum, I. R. Miousse

The paper shows that methionine stress induces a ferroptotic gene signature in methionine-dependent cancer cells, which is reduced in methionine-independent cells.

bioRxiv · Aug 18, 2020 · PreprintCancer Biology