Author

C. Beninca

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:metabolomics· 2

Frequent Co-Authors

A. E. Jones· 2 shared A. S. Divakaruni· 2 shared L. Stiles· 2 shared M. Zeviani· 2 shared O. S. Shirihai· 2 shared A. Acevedo· 1 shared A. B. Ball· 1 shared A. Chacinska· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

A. E. Jones

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Pro-inflammatory macrophage activation does not require inhibition of mitochondrial respiration

A. B. Ball, A. E. Jones, K. B. Nguyen, A. Rios, N. Marx, W. Y. Hsieh, K. Yang, B. R. Desousa, K. K. O. Kim, M. Veliova, Z. M. del Mundo, O. S. Shirihai, C. Beninca, L. Stiles, S. J. Bensinger, A. S. Divakaruni

This study shows that reduced oxidative phosphorylation is not required for pro-inflammatory macrophage activation, challenging the conventional model of mitochondrial reprogramming.

bioRxiv · May 10, 2024 · PreprintImmunology

The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis

A. Acevedo, A. E. Jones, B. T. Danna, R. Turner, K. P. Montales, C. Beninca, K. Reue, O. S. Shirihai, L. Stiles, M. Wallace, Y. Wang, A. M. Bertholet, A. S. Divakaruni

The paper shows BT2 acts as a mitochondrial uncoupler, reducing ROS and lipogenesis, which may explain its therapeutic benefits in metabolic diseases.

bioRxiv · Aug 15, 2023 · PreprintBiochemistry

A novel Alex3/Gαq protein complex regulating mitochondrial dynamics, dendritic complexity, and neuronal survival

I. Izquierdo-Villalba, S. Mirra, Y. Manso, A. Parcerisas, J. Rubio, J. Del Valle, M. Herrero-Lorenzo, F. Ulloa, F. J. Gil-Bea, M. Herrero-Lorenzo, C. Beninca, R. D. Castro-Torres, E. Rebollo, G. Marfany, C. Auladell, , E. Soriano

This study identifies a novel Alex3/Gαq complex that regulates mitochondrial dynamics, dendritic complexity, and neuronal survival through calcium-dependent disassembly.

bioRxiv · Dec 9, 2021 · PreprintCell Biology

Opa1 overexpression protects from early onset Mpv17-/--related mouse kidney disease

M. Zeviani, M. Luna-Sanchez, C. Beninca, R. Cerutti, A. Yeats, L. Scorrano, C. Viscomi, G. Brea Calvo

This study shows that moderate Opa1 overexpression in Mpv17-/- mice delays kidney disease progression by preserving mitochondrial structure and function.

bioRxiv · Mar 18, 2020Pathology

Inhibition of proteasomal degradation rescues a pathogenic variant of mitochondrial Respiratory chain assembly 1 factor

K. Mohanraj, M. Wasilewski, C. Beninca, D. Cysewski, J. Poznanski, P. Sakowska, M. Deckers, S. Dennerlein, E. Fernandez-Vizarra, P. Rehling, M. Dadlez, M. Zeviani, A. Chacinska

This study shows that inhibiting proteasome degradation rescues mutant RESA1 protein function and complex IV activity in patient-derived fibroblasts.

bioRxiv · Jul 24, 2018Biochemistry

Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin

J. J. Lee, A. Sanchez-Martinez, A. Martinez Zarate, C. Beninca, U. Mayor, M. J. Clague, A. J. Whitworth

The paper investigates the role of PINK1 and parkin in basal mitophagy in Drosophila, finding no significant impact on basal mitophagy despite locomotor defects and dopaminergic neuron loss.

bioRxiv · Jan 12, 2018Cell Biology