A. K. Das

Designing a Novel 3D Scaffold for Multiepitope Vaccine Development: Engineering Ag85a Protein for Enhanced Stability and Antigenicity

This study designs a scaffold-based multiepitope vaccine against tuberculosis by engineering the Ag85A protein to enhance stability and antigenicity through computational methods.

Apolipoprotein-E transforms intracellular Amyloid-β oligomers to a more toxic state

The paper shows ApoE modifies Aβ oligomers to a more toxic form, detectable in live cells, and presents a potential assay for AD drug discovery.

Putative staphylococcal enterotoxin possesses two common structural motifs for MHC-II binding

This study characterizes a putative staphylococcal enterotoxin, SEl26, showing its structural similarity to conventional SAgs and its ability to bind MHC-II and modulate cytokines.

Targeting staphylococcal cell-wall biosynthesis protein FemX through steered molecular dynamics and drug-repurposing approach

This study repurposes FDA-approved drugs against S. aureus by analyzing their binding to FemX using SMD and shows Lumacaftor has higher affinity and lower toxicity.

In silico and in vitro characterization of the mycobacterial protein Ku to unravel its role in non-homologous end-joining DNA repair

The paper characterizes the DNA binding properties of mycobacterial Ku (mKu) and its role in NHEJ using in silico and in vitro methods, showing its ability to stabilize DNA and protect termini from degradation.

Targeting an evolutionarily conserved "E-L-L" motif in the spike protein to develop a small molecule fusion inhibitor against SARS-CoV-2

This study identifies an evolutionarily conserved 'E-L-L' motif in the SARS-CoV-2 spike protein as a target for small molecule fusion inhibitors, showing posaconazole effectively blocks viral entry across variants.

Wnt5A Signaling Blocks Progression of Experimental Visceral Leishmaniasis

This study shows that Wnt5A signaling reduces susceptibility to visceral leishmaniasis by limiting infection progression and preserving immune cell function in mice.

Redox Nanomedicine Cures Chronic Kidney Disease (CKD) by Mitochondrial Reconditioning

This study demonstrates that a redox nanomedicine, C-Mn3O4 NPs, treats CKD by restoring mitochondrial function and redox balance in animal models.

Redox Buffering Capacity of Nanomaterials as an Index of ROS-based Therapeutics and Toxicity: A Preclinical Animal Study

This study evaluates the redox buffering capacity of nanomaterials to assess their therapeutic potential and toxicity in a preclinical animal model.

A Nanoceutical Agent for Chemoprevention of Bilirubin Encephalopathy

This paper reports on the development and testing of citrate-functionalized Mn3O4 nanoparticles for the prevention of bilirubin encephalopathy in a mouse model of neonatal hyperbilirubinemia.

Utilization and prospectus of non-timber forest products as livelihood materials

The paper assesses the current use of non-timber forest products in the Sundarbans and explores their potential alternative uses to improve sustainability and socio-economic conditions.

Incorporation of a Biocompatible Nanozyme in Cellular Antioxidant Enzyme Cascade Reverses Huntington's Like Disorder in Preclinical Model

This paper demonstrates that a biocompatible nanozyme can reverse Huntington's-like disorder in a preclinical model by mimicking glutathione peroxidase and integrating into the cellular antioxidant cascade.

Development of a copper-graphene nanocomposite based transparent coating with antiviral activity against influenza virus

This paper develops a copper-graphene nanocomposite transparent coating with antiviral activity against influenza virus, showing rapid inactivation of virions and reduced viral replication.

Unique PKD like protein kinase in Entamoeba histolytica regulates vital actin mediated processes

This study identifies and characterizes EhPKDL, a PKD-like protein kinase in Entamoeba histolytica that nucleates actin polymerization and is essential for actin-mediated processes like erythrophagocytosis.