Author

A. K. Lam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. E. Floru· 1 shared A. Sukhina· 1 shared B. J. Iorgulescu· 1 shared C. Ceol· 1 shared C. Evans-Molina· 1 shared C. F. Ware· 1 shared C. J. Wu· 1 shared C.-T. Liu· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperCancer Biology

A. E. Floru

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Author profile →

3 papers

Recent·Most cited

β Cell microRNAs Function as Molecular Hubs of Type 1 Diabetes Pathogenesis and as Biomarkers of Diabetes Risk

F. Syed, P. Krishnan, G. Chang, S. R. Langlais, S. Hati, K. Yamada, A. K. Lam, S. Talware, X. Liu, R. Sardar, J. Liu, R. G. Mirmira, C. Evans-Molina

The paper identifies miRNAs in human islets and EVs that change under inflammatory conditions and can serve as biomarkers for type 1 diabetes risk.

bioRxiv · Jun 15, 2023 · PreprintPhysiology

Treg cells drive MYCN-mediated immunosuppression and tumor aggressiveness in high-risk neuroblastoma

X. Qin, A. K. Lam, X. Zhang, S. Sengupta, B. J. Iorgulescu, T. Zuo, A. E. Floru, G. K. Meara, k. Lloyd, L. A. Kwok, K. S. Smith, T. R. Nagaraju, R. Meijers, C. Ceol, C.-T. Liu, , H. Feng

This study shows Treg cells drive MYCN-mediated immunosuppression and tumor aggressiveness in high-risk neuroblastoma using human and zebrafish models.

bioRxiv · Oct 3, 2022 · PreprintCancer Biology

Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses

G. Brar, N. A. Farhat, A. Sukhina, A. K. Lam, Y. H. Kim, T. Hsu, L. Tong, W. W. Lin, C. F. Ware, M. A. Blackman, R. Sun, T.-T. Wu

This paper develops a herpesvirus vaccine by deleting immune evasion genes to enhance immunogenicity and safety, showing durable protection against latency in a mouse model.

bioRxiv · Apr 13, 2020Microbiology