Author

T. S. Griffith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1

Frequent Co-Authors

V. P. Badovinac· 4 shared K. E. Remy· 2 shared L. L. Moldawer· 2 shared M. B. Mazer· 2 shared M. Rao· 2 shared P. A. Efron· 2 shared P. W. McGonagill· 2 shared R. S. Hotchkiss· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersImmunology

V. P. Badovinac

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5 papers

Recent·Most cited

Development and optimization of a diluted whole blood ELISpot assay to test immune function

R. F. Ungaro, J. Xu, T. A. Kucaba, M. Rao, S. C. Brakenridge, P. A. Efron, R. W. Gould, R. S. Hotchkiss, M. B. Mazer, P. W. McGonagill, L. L. Moldawer, K. E. Remy, I. R. Turnbull, C. C. Caldwell, V. P. Badovinac, T. S. Griffith

This study develops and optimizes a diluted whole blood ELISpot assay to assess immune function in septic patients, showing it can measure cytokine responses under various conditions.

bioRxiv · Jan 20, 2024Immunology

Temporal Changes in Innate and Adaptive Immunity During Sepsis as Determined by ELISpot

A. H. Walton, R. S. Hotchkiss, D. Osborne, J. Unsinger, E. H. Han, L. Sheets, M. B. Mazer, K. E. Remy, T. S. Griffith, M. Rao, V. P. Badovinac, S. C. Brakenridge, I. Turnbull, P. A. Efron, L. L. Moldawer, C. C. Calwell

This study uses ELISpot to track changes in innate and adaptive immunity during sepsis and shows it can detect immune therapy effects.

bioRxiv · Dec 14, 2023Immunology

Hepatic IRE1 Protects Against Septic Cardiac Failure

M. Li, R. R. Berton, Q. Qian, J. A. Maschek, B. Chen, E. Barroso, A. Rauckhorst, T. S. Griffith, E. B. Taylor, J. E. Cox, V. P. Badovinac, G. S. Hotamisligil, L.-s. Song, L. Yang

This study shows that hepatic IRE1 protects against septic cardiac failure by maintaining lipid metabolic balance, independent of inflammation.

bioRxiv · Mar 14, 2023 · PreprintPathology

A subset of CD4+ effector memory T cells limit immunity to pulmonary viral infection and prevent tissue pathology via activation of latent TGFβ

C. P. McEntee, S. Houston, C. M. Finlay, S. Rossi, G. Liu, T. N. Shaw, J. Casulli, M. Fife, C. Smedley, T. S. Griffith, M. Pepper, T. Hussell, P. M. Hansbro, J.-M. Schwartz, H. Paidassi, M. A. Travis

The paper identifies a subset of CD4+ effector memory T cells that limit secondary immune responses to viral re-infection and prevent lung pathology by activating latent TGFβ.

bioRxiv · Mar 2, 2023 · PreprintImmunology

Autoimmunity increases susceptibility to and mortality from sepsis

I. J. Jensen, S. N. Jensen, P. W. McGonagill, T. S. Griffith, A. K. Mangalam, V. P. Badovinac

The paper shows that autoimmune disease increases sepsis susceptibility and mortality using mouse models and clinical data.

bioRxiv · Jul 6, 2021Immunology