Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation
A. K. Meyers, Z. Wang, W. Han, Q. Zhao, M. Zabalawi, L. Duan, J. Liu, Q. Zhang, R. K. Manne, F. Lorenzo, M. A. Quinn, Q. Song, D. Fan, H.-K. Lin, C. M. Furdui, , X. Zhu
This study shows that inhibiting PDHK reduces NLRP3 inflammasome activation in macrophages, decreasing inflammation and tissue damage.
Cell Reports · Jan 1, 2023Peer-reviewedImmunology