Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
F. Jradi, B. P. English, T. A. Brown, J. Arron, S. Khuon, J. A. Galbraith, C. G. Galbraith, L. D. Lavis
This paper introduces a method to create photochromic and blinking fluorophores by combining rhodamine and coumarin dyes, enhancing SMLM labeling options.
bioRxiv · May 12, 2024 · PreprintCell Biology
K. L. Holland, S. E. Plutkis, T. A. Daugird, A. Sau, J. B. Grimm, B. P. English, Q. Zheng, S. Dave, F. Rahman, L. Xie, P. Dong, A. N. Tkachuk, T. A. Brown, R. H. Singer, Z. J. Liu, , L. D. Lavis
This paper introduces a series of spontaneously blinking dyes with adjustable duty cycles for improved single-molecule localization microscopy in cells and dense structures.
bioRxiv · Feb 23, 2024Cell Biology
R. J. Farrell, K. G. Bredvik, M. B. Hoppa, S. T. Hennegan, T. A. Brown, T. A. Ryan
The paper develops a ratiometric ER calcium sensor to enable quantitative comparisons of ER Ca2+ levels across cell types and subcellular regions, showing lower resting Ca2+ in neurons compared to fibroblasts.
bioRxiv · Feb 15, 2024 · PreprintCell Biology
P. Kumar, A. Gutu, A. Waring, T. A. Brown, L. D. Lavis, A. G. Tebo
The paper develops novel fluorogens that activate FAST proteins and convert splitFAST systems into chemical dimerizers, reducing the need for protein engineering.
bioRxiv · Dec 30, 2023 · PreprintBiochemistry
J. S. Marvin, A. C. Kokotos, M. Kumar, C. Pulido, A. N. Tkachuk, J. S. Yao, T. A. Brown, T. A. Ryan
The paper develops iATPSnFR2, a high dynamic range fluorescent ATP sensor for real-time subcellular ATP monitoring, showing improved performance over previous versions.
bioRxiv · Aug 24, 2023Biochemistry
K. Davidsen, J. S. Marvin, A. Aggarwal, T. A. Brown, L. B. Sullivan
This paper develops a GFP-based biosensor to dynamically measure aspartate levels in living cells, showing it correlates with mass spectrometry measurements and detects temporal changes in aspartate concentration.
bioRxiv · Jun 27, 2023Biochemistry
J. B. Grimm, L. Xie, J. C. Casler, R. Patel, A. N. Tkachuk, H. Choi, J. Lippincott-Schwartz, T. A. Brown, B. S. Glick, Z. Liu, L. D. Lavis
This study shows that deuteration of small-molecule fluorophores enhances their brightness, chromostability, and photostability in cellular imaging.
bioRxiv · Aug 17, 2020 · PreprintCell Biology
J. B. Grimm, A. N. Tkachuk, H. Choi, B. Mohar, N. Falco, R. Patel, J. Lippincott-Schwartz, T. A. Brown, L. D. Lavis
This study optimizes red-shifted rhodamine dyes to improve their performance and enables functionalization with different chemical groups.
bioRxiv · Dec 20, 2019 · PreprintCell Biology
J. B. Grimm, A. K. Muthusamy, Y. Liang, T. A. Brown, W. C. Lemon, R. Patel, R. Lu, J. J. Macklin, P. J. Keller, N. Ji, L. D. Lavis
The paper introduces a method to fine-tune fluorophores for improved brightness and photostability in live-cell and in vivo imaging.
bioRxiv · Apr 14, 2017Cell Biology