Author

T. G. Fazzio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

S. Gopalan· 3 shared L. J. Zhu· 2 shared A. A. Godbole· 1 shared A. D. Durbin· 1 shared A. K. Walker· 1 shared A. Kulick· 1 shared A. L. Munden· 1 shared A. N. Imbalzano· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCancer Biology

S. Gopalan

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Author profile →

5 papers

Recent·Most cited

PRMT5 orchestrates EGFR and AKT networks to activate NFκB and promote EMT

L. Huang, M. Ravi, X.-O. Zhang, O. Verdejo-Torres, N. A. M. Shendy, M. A. M. Nezhady, S. Gopalan, G. Wang, A. D. Durbin, T. G. Fazzio, J. Q. Wu

This study identifies PRMT5's role in promoting EMT in neuroblastoma by regulating EGFR and AKT pathways, leading to NFκB activation and tumor growth.

bioRxiv · Jan 3, 2024 · PreprintCancer Biology

Phosphosite Scanning reveals a complex phosphorylation code underlying CDK-dependent activation of Hcm1

M. M. Conti, R. Li, M. A. Narvaez Ramos, L. J. Zhu, T. G. Fazzio, J. A. Benanti

The paper introduces Phosphosite Scanning to identify functionally important phosphosites in multisite phosphorylated domains, demonstrating its application to Hcm1 in yeast.

bioRxiv · Aug 4, 2022Cell Biology

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

L. Chibaya, K. C. Murphy, Y. Lopez-Diaz, K. D. DeMarco, H. Liu, S. Gopalan, M. Faulkner, J. Li, J. P. Morris, Y.-J. Ho, J. Simon, W. Luan, A. Kulick, E. De Stanchina, K. Simin, , M. Ruscetti

This study shows that inhibiting EZH2 enhances pro-inflammatory SASP in pancreatic cancer, improving NK and T cell infiltration and tumor control in mouse models.

bioRxiv · Jun 21, 2022Cancer Biology

S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress

A. A. Godbole, S. Gopalan, T.-K. Nguyen, A. L. Munden, P. Vo, C. A. Lewis, J. B. Spinelli, T. G. Fazzio, A. K. Walker

The paper identifies distinct roles of SAMS-1 and SAMS-4 in regulating H3K4me3 and gene expression during heat stress in C. elegans.

bioRxiv · Mar 30, 2022Cell Biology

MTF1, a classic metal sensing transcription factor, promotes myogenesis in response to copper.

C. Tavera-Montanez, S. J. Hainer, D. Cangussu, S. J. V. Gordon, Y. Xiao, P. Reyes-Gutierrez, A. N. Imbalzano, J. G. Navea, T. G. Fazzio, T. PADILLA-BENAVIDES

This study identifies a role for MTF1 and copper in promoting myogenesis by enhancing MTF1 expression and its interaction with myogenic genes.

bioRxiv · Jun 14, 2019Cell Biology