Evolutionary transcriptomics reveals longevity mostly driven by polygenic and indirect selection in mammals
W. Liu, P. Zhu, M. Li, Z. Li, Y. Yu, G. Liu, J. Du, X. Wang, J. Yang, R. Tian, I. Seim, A. Kaya, M. Li, M. Li, V. N. Gladyshev, X. Zhou
This study uses comparative transcriptomics across mammals to show that longevity is influenced by polygenic and indirect selection, with key pathways like insulin signaling showing correlations with lifespan.
bioRxiv · Jan 9, 2023Evolutionary Biology