Author

A. Korkegian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

T. Parish· 4 shared Y. Ovechkina· 3 shared J. Odingo· 2 shared L. Flint· 2 shared B. Berube· 1 shared B. Sunde· 1 shared C. D. Shelton· 1 shared D. B. Olsen· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersMicrobiology

T. Parish

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4 papers

Recent·Most cited

Identification of 2-amino benzothiazoles with bactericidal activity against Mycobacterium tuberculosis

S. A. Bonnett, J.-A. Jee, S. Chettiar, Y. Ovechkina, A. Korkegian, E. Greve, J. Odingo, T. Parish

The paper identifies 2-amino benzothiazoles with bactericidal activity against Mycobacterium tuberculosis, showing improved potency and reduced cytotoxicity but poor metabolic stability.

bioRxiv · Sep 23, 2022 · PreprintMicrobiology

Triazolopyrimidines target aerobic respiration in Mycobacterium tuberculosis

C. D. Shelton, M. B. McNeil, L. Flint, D. Russell, B. Berube, A. Korkegian, Y. Ovechkina, T. Parish

This study identifies triazolopyrimidines as inhibitors of Mycobacterium tuberculosis cytochrome bc1 complex, showing resistance linked to QcrB mutations and efficacy against intracellular bacteria.

bioRxiv · Oct 18, 2021Microbiology

InhA inhibitors have activity against non-replicating Mycobacterium tuberculosis

L. Flint, A. Korkegian, T. Parish

The paper tests two diazaborine molecules against non-replicating Mycobacterium tuberculosis and finds they reduce viability by >3 logs in 21 days.

bioRxiv · Aug 19, 2020Microbiology

Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis

S. B. Singh, J. Odingo, M. A. Bailey, B. Sunde, A. Korkegian, T. O'Malley, Y. Ovechkina, T. R. Ioerger, J. C. Sacchettini, K. Young, D. B. Olsen, T. Parish

The paper screens 500 natural products for anti-tubercular activity, identifies five active cyclic hexapeptides, and shows structural analogs lack activity.

bioRxiv · Mar 10, 2018Microbiology