S. Iwami

Stable platelet production via the bypass pathway explains the long-term reconstitution capacity of hematopoietic stem cells

This study identifies a myeloid bypass pathway that supports long-term HSC reconstitution by analyzing single-cell transplantation data with a mathematical model.

Stratification of viral shedding patterns in saliva of COVID-19 patients

This study stratifies SARS-CoV-2 viral shedding patterns in saliva into three groups with distinct durations using a mathematical model and clustering, but finds no clear clinical or miRNA biomarkers explaining the differences.

Direct Relationship between Protein Expression and Progeny Yield of Herpes Simplex Virus 1 Unveils a Rate-limiting Step for Virus Production

This study identifies a direct relationship between viral protein expression and progeny yield in herpes simplex virus 1, revealing DNA cleavage/packaging as a rate-limiting step for virus production.

Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation for analyzing extracellular viral markers

This study develops a multiscale mathematical model to predict intrahepatic cccDNA dynamics using serum viral markers, offering a non-invasive method for HBV infection analysis.

Isolation may select for earlier and higher peak viral load but shorter duration in SARS-CoV-2 evolution

This study shows isolation measures during the pandemic selected for SARS-CoV-2 variants with earlier and higher peak viral loads but shorter infection duration.

Contact-number-driven virus evolution: a multi-level modeling framework for the evolution of acute or persistent RNA virus infection

This study models virus evolution under different contact histories, finding that high-contact environments favor acute infections while low-contact environments favor persistent infections.

Prediction of elimination of intrahepatic cccDNA in hepatitis B virus-infected patients by a combination of noninvasive viral markers

This study develops a noninvasive method using viral markers to predict cccDNA levels in HBV patients, validated against liver biopsy data.

Potential anti-monkeypox virus activity of atovaquone, mefloquine, and molnupiravir, and their potential use as treatments

This study identifies atovaquone, mefloquine, and molnupiravir as potential anti-monkeypox virus drugs, with atovaquone showing enhanced efficacy when combined with tecovirimat.

Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2

The paper compares the efficacy of neutralizing antibodies and antiviral drugs against SARS-CoV-2 Omicron subvariants BA.1 and BA.2, finding differential responses to specific treatments.

Characterization of various remdesivir-resistant mutations of SARS-CoV-2 by mathematical modeling and molecular dynamics simulation.

This study identifies remdesivir-resistant SARS-CoV-2 mutations using viral reconstruction, mathematical modeling, and molecular dynamics simulations, showing mutations reduce antiviral activity without increasing viral production.

A widely-distributed HIV-1 provirus elimination assay to evaluate latency-reversing agents in vitro

The paper develops a new assay to evaluate latency-reversing agents by eliminating HIV-1 proviruses in a long-term cell culture system.

Anti-severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) potency of Mefloquine as an entry inhibitor in vitro

This study identifies Mefloquine as a potent in vitro entry inhibitor of SARS-CoV-2 with higher antiviral activity than Hydroxychloroquine.

Identification of novel avian and mammalian deltaviruses provides new insights into deltavirus evolution

This study identifies novel deltaviruses in birds and mammals, revealing evolutionary relationships and transmission dynamics of deltaviruses.

Multidrug treatment with nelfinavir and cepharanthine against COVID-19

This study identifies a new multidrug combination treatment for COVID-19 using nelfinavir and cepharanthine, showing synergistic antiviral effects and improved disease control.

Direct evidence of abortive lytic infection-mediated establishment of Epstein-Barr virus latency during B-cell infection

The paper tracks EBV infection in B-cells using fate mapping and RNA-seq, showing abortive lytic infection precedes latency.

Modeling the efficiency of filovirus entry into cells in vitro: Effects of SNP mutations in the receptor molecule

The paper models how SNP mutations in NPC1 affect filovirus entry efficiency using in vitro experiments and a mathematical model.

Two strategies underlying the trade-off of hepatitis C virus proliferation: stay-at-home or leaving-home?

This study analyzes the trade-off between two HCV proliferation strategies, finding that Jc1-n favors transmission while JFH-1 favors intracellular replication.