Author

J. Secklehner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:imaging· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Assay:flow cytometry· 1

Frequent Co-Authors

A. J. McFarlane· 3 shared J. B. G. Mackey· 3 shared L. M. Carlin· 3 shared D. J. Murphy· 2 shared F. Fercoq· 2 shared J. Vuononvirta· 2 shared K. De Filippo· 2 shared X. L. Raffo-Iraolagoitia· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

A. J. McFarlane

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4 papers

Recent·Most cited

eATP/P2X7R axis drives nanoparticle induced neutrophil recruitment in the pulmonary microcirculation

C. Li, Q. Liu, L. Han, R. Immler, B. Rathkolb, J. Secklehner, M. Hrabe de Angelis, A. O. Yildirim, A. Nicke, L. M. Carlin, M. Sperandio, T. Stoeger, M. Rehberg

This study identifies the eATP/P2X7R axis as a driver of nanoparticle-induced neutrophil recruitment in the pulmonary microcirculation using intravital microscopy in mice.

bioRxiv · Mar 11, 2024 · PreprintImmunology

γδ T cells impair airway macrophage differentiation in lung adenocarcinoma

X. L. Raffo-Iraolagoitia, A. J. McFarlane, B. Kruspig, F. Fercoq, J. Secklehner, M. De Donatis, J. B. G. Mackey, R. Wiesheu, S. Laing, Y.-C. Hsieh, R. Shaw, R. Corbyn, C. Nixon, C. Miller, K. Kirschner, , L. M. Carlin

The paper identifies that CD27+ γδ T cells impair the differentiation of tumor-associated macrophages into airway macrophages in lung adenocarcinoma.

bioRxiv · Sep 14, 2023Immunology

Maturation, developmental site, and pathology dictate murine neutrophil function

J. B. G. Mackey, A. J. McFarlane, T. Jamieson, R. Jackstadt, X. L. Raffo-Iraolagoitia, J. Secklehner, X. Cortes-Lavaud, F. Fercoq, W. Clarke, A. Hedley, K. Gilroy, S. Lilla, J. Vuononvirta, G. J. Graham, K. De Filippo, , L. M. Carlin

This study identifies Ly6G expression levels as a marker for neutrophil maturation stages and shows spleen-derived neutrophils mature faster with distinct transcriptional profiles.

bioRxiv · Jul 21, 2021 · PreprintImmunology

Pulmonary natural killer cells control neutrophil intravascular motility and response to acute inflammation

J. Secklehner, K. De Filippo, J. B. G. Mackey, J. Vuononvirta, X. L. Raffo Iraolagoitia, A. J. McFarlane, M. Neilson, M. B. Headley, M. F. Krummel, N. Guerra, L. Carlin

This study shows pulmonary natural killer cells reduce neutrophil accumulation during inflammation by altering their motility.

bioRxiv · Jun 23, 2019 · PreprintImmunology