Author

A. P. Makohon-Moore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 4 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:whole-genome sequencing· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. A. Iacobuzio-Donahue· 5 shared L. Zhang· 4 shared A. Hayashi· 3 shared J. Hong· 3 shared J. Huang· 3 shared R. Kappagantula· 3 shared H. Sakamoto· 2 shared J. P. Melchor· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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5 shared papersCancer Biology

C. A. Iacobuzio-Donahue

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Author profile →

5 papers

Recent·Most cited

Pancreatic cancer prognosis is predicted by a novel ATAC-array technology for assessing chromatin accessibility

S. Dhara, S. Chhangawala, H. Chintalapudi, G. Askan, V. Aveson, A. L. Massa, L. Zhang, A. P. Makohon-Moore, N. Lecomte, J. P. Melchor, J. Bermeo, A. Cardenas, S. Sinha, D. Glassman, R. Nicolle, , S. D. Leach

The paper develops ATAC-Array, a low-cost chromatin accessibility assay, and shows it predicts pancreatic cancer prognosis based on chromatin accessibility patterns.

bioRxiv · Jan 21, 2021Cancer Biology

Selection for Decreased BRCA2 Functional Activity in Homo sapiens After Divergence from the Chimpanzee-Human Last Common Ancestor

C. A. Iacobuzio-Donahue, J. Huang, Y. Zhong, A. P. Makohon-Moore, T. White, M. Jasin, M. A. Norell, W. C. Wheeler

The paper identifies a human-specific BRCA2 variant that reduces DNA repair ability, suggesting positive selection for decreased BRCA2 function in human evolution.

bioRxiv · Nov 16, 2020 · PreprintEvolutionary Biology

Evolutionary Dynamics of Non-Coding Regions in Pancreatic Ductal Adenocarcinoma

A. Hayashi, Y.-j. Ho, A. P. Makohon-Moore, A. Zucker, J. Hong, J. G. Reiter, J. Huang, L. Zhang, M. A. Attiyeh, P. Baez, R. Kappagantula, J. P. Melchor, E. M. OReilly, N. D. Socci, S. Oki, , C. A. Iacobuzio-Donahue

This study investigates the evolutionary dynamics of non-coding regions in pancreatic cancer, finding higher mutational burden in noncoding DNA and similar mutational spectra between enhancers and coding DNA.

bioRxiv · Sep 11, 2020 · PreprintCancer Biology

Evolutionary Origins of Recurrent Pancreatic Cancer

H. Sakamoto, M. Attiyeh, J. Gerold, A. P. Makohon-Moore, A. Hayashi, J. Hong, R. Kappagantula, L. Zhang, J. Melchor, J. Reiter, A. Heyde, C. Bielski, A. Penson, D. Chakravarty, E. O'Reilly, , C. A. Iacobuzio-Donahue

This study identifies genetic features of recurrent pancreatic cancer through sequencing and finds that treatment-induced genetic changes and potential second primary tumors influence recurrence.

bioRxiv · Oct 31, 2019Cancer Biology

The Genetic Basis of Transcriptional and Spatial Heterogeneity of Basal-Like Features in Pancreatic Ductal Adenocarcinoma

A. Hayashi, J. Fan, R. Chen, Y.-j. Ho, A. P. Makohon-Moore, Y. Zhong, J. Hong, H. Sakamoto, M. A. Attiyeh, Z. A. Kohutek, L. Zhang, J. Huang, A. Boumiza, R. Kappagantula, P. Baez, , C. A. Iacobuzio-Donahue

The paper identifies genetic and transcriptional features of basal-like subtypes in pancreatic ductal adenocarcinoma, linking them to squamous histology and chromatin modifier mutations.

bioRxiv · Apr 4, 2019 · PreprintCancer Biology