H. Sakamoto

Suppressive effects of oroxylin A on intracellular proliferation of Toxoplasma gondii via host cell ERK phosphorylation inhibition

This study shows oroxylin A inhibits Toxoplasma gondii intracellular growth by blocking host cell ERK phosphorylation, similar to MEK1 inhibitors.

NDR1 and the Arabidopsis Plasma Membrane ATPase AHA5 are Required for Processes that Converge on Drought Tolerance and Immunity

This study shows NDR1 is required for drought tolerance and immunity by regulating H+-ATPase activity and stomatal dynamics in Arabidopsis.

Revisiting the gastrin-releasing peptide/bombesin system: A reverse-evolutionary study considering Xenopus

This study investigates the evolutionary relationships of the gastrin-releasing peptide (GRP) and bombesin systems in vertebrates using Xenopus tropicalis, showing GRP is not a mammalian counterpart of bombesin and that the NMB/bombesin system has diversified in frogs.

Impaired expression of chloroplast HSP90C chaperone activates plant defense responses leading to a disease symptom-like phenotype

The paper shows that silencing chloroplast HSP90C in tobacco causes chlorosis via downregulation of photosynthesis genes and activation of immune responses including cell death.

Evolutionary Origins of Recurrent Pancreatic Cancer

This study identifies genetic features of recurrent pancreatic cancer through sequencing and finds that treatment-induced genetic changes and potential second primary tumors influence recurrence.

The Genetic Basis of Transcriptional and Spatial Heterogeneity of Basal-Like Features in Pancreatic Ductal Adenocarcinoma

The paper identifies genetic and transcriptional features of basal-like subtypes in pancreatic ductal adenocarcinoma, linking them to squamous histology and chromatin modifier mutations.