Author

P. S. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. Bermingham· 2 shared A. Frommlet· 2 shared A. Lingel· 2 shared A. O. Frank· 2 shared A. Ruzin· 2 shared B. Benton· 2 shared C. J. Balibar· 2 shared C. M. Baxter Rath· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

A. Bermingham

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Autoregulation of a trimeric transporter involves the cytoplasmic domains of both adjacent subunits

V. Leone, R. T. Bradshaw, C. Koshy, P. S. Lee, C. Fenollar-Ferrer, V. Heinz, C. Ziegler, L. R. Forrest

This study uses molecular simulations to analyze the autoregulatory domains of BetP, showing how C-terminal tails interact with neighboring subunits and how N-terminal tails may also contribute to regulation.

bioRxiv · Jun 5, 2022Biochemistry

A theoretical framework to study the influence of electrical fields on mesenchymal stem cells

J. Dawson, P. S. Lee, U. v. Rienen, R. Appali

This paper develops a theoretical framework to model how electric fields influence mesenchymal stem cell dynamics, showing that differentiation rates depend on electric fields and cell density.

bioRxiv · May 4, 2020Biophysics

Two distinct mechanisms of small molecule inhibition of LpxA acyltransferase essential for lipopolysaccharide biosynthesis

W. Han, X. Ma, C. J. Balibar, C. M. Baxter Rath, B. Benton, A. Bermingham, F. Casey, B. Chie-Leon, M.-K. Cho, A. O. Frank, A. Frommlet, C.-M. Ho, P. S. Lee, M. Li, A. Lingel, , T. Uehara

The paper identifies two distinct mechanisms by which small molecules inhibit LpxA acyltransferase, a key enzyme in lipopolysaccharide biosynthesis.

bioRxiv · Dec 17, 2019 · PreprintBiochemistry

Two distinct mechanisms of small molecule inhibition of LpxA acyltransferase essential for lipopolysaccharide biosynthesis

W. Han, X. Ma, C. J. Balibar, C. M. Baxter Rath, B. Benton, A. Bermingham, F. Casey, B. Chi-Leon, M.-K. Cho, A. O. Frank, A. Frommlet, C.-M. Ho, P. S. Lee, M. Li, A. Lingel, , T. Uehara

This study identifies two small-molecule inhibitors of LpxA, revealing distinct inhibition mechanisms and highlighting compound 2's improved properties for antibacterial development.

bioRxiv · Dec 14, 2019 · PreprintBiochemistry

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications

C. C. Ward, J. I. Kleinman, S. M. Brittain, P. S. Lee, C. Y. S. Chung, K. Kim, Y. Petri, J. R. Thomas, J. A. Tallarico, J. M. McKenna, M. Schirle, D. K. Nomura

This study identifies a covalent ligand for RNF4, an E3 ligase, and demonstrates its use in designing a bifunctional degrader that effectively degrades BRD4.

bioRxiv · Nov 16, 2018Biochemistry