Author

J. C. Davies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. M. Edwards· 3 shared A. Sabnis· 2 shared G. Larrouy-Maumus· 2 shared R. A. Murphy· 2 shared T. Vorup-Jensen· 2 shared A. A. Sabnis· 1 shared A. Klockner· 1 shared D. A. I. Mavridou· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMicrobiology

A. M. Edwards

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Antimicrobial peptide glatiramer acetate targets Pseudomonas aeruginosa lipopolysaccharides to breach membranes without altering lipopolysaccharide modification

R. A. Murphy, J. Pizzato, L. Cuthbertson, A. A. Sabnis, A. M. Edwards, L. M. Nolan, T. Vorup-Jensen, G. Larrouy-Maumus, J. C. Davies

This study shows glatiramer acetate binds and neutralizes Pseudomonas aeruginosa lipopolysaccharides and extracellular DNA, enhancing antibiotic efficacy without inducing resistance mechanisms.

bioRxiv · May 23, 2023 · PreprintMicrobiology

Synergistic Activity of Repurposed Peptide Drug Glatiramer Acetate with Tobramycin Against Cystic Fibrosis Pseudomonas aeruginosa

R. A. Murphy, M. Coates, S. Thrane, A. Sabnis, J. Harrison, S. Schelenz, A. M. Edwards, T. Vorup-Jensen, J. C. Davies

This study shows that glatiramer acetate enhances tobramycin's effectiveness against Pseudomonas aeruginosa in cystic fibrosis patients by reducing MICs and disrupting bacterial membranes.

bioRxiv · Feb 3, 2022Microbiology

Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

A. Sabnis, K. L. H. Hagart, A. Klockner, M. Becce, L. E. Evans, R. C. D. Furniss, D. A. I. Mavridou, R. Murphy, M. M. Stevens, J. C. Davies, G. Larrouy-Maumus, T. B. Clarke, A. M. Edwards

This study reveals that colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane, not the outer membrane, and shows that murepavadin can enhance its efficacy.

eLife · Apr 6, 2021Peer-reviewedMicrobiology

Response of Pseudomonas aeruginosa to the innate immune system-derived oxidants hypochlorous acid and hypothiocyanous acid

K. V. Farrant, L. Spiga, J. C. Davies, H. D. Williams

This study identifies RclR as a key regulator of Pseudomonas aeruginosa's response to HOCl and HOSCN, revealing its role in upregulating stress response genes and coordinating survival mechanisms.

bioRxiv · Jan 9, 2020Microbiology