Author

A. B. van Spriel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. G. Figdor· 3 shared A. van Duffelen· 2 shared E. Jansen· 2 shared L. Querol Cano· 2 shared A. B. Arp· 1 shared A. Bartolo-Ibars· 1 shared A. Cambi· 1 shared A. L. Matthews· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCell Biology

C. G. Figdor

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Immunofilaments Provide a Nanoscale Platform for In Vivo T Cell Expansion and Cancer Immunotherapy

L. Weiss, J. Weiden, Y. Dölen, E. Grad, E. A. W. van Dinther, M. Schluck, L. J. Eggermont, G. van Mierlo, U. Gileadi, A. Bartolo-Ibars, R. Raave, M. A. J. Gorris, K. Verrijp, M. Valente, B. Deplancke, , R. Hammink

This paper introduces immunofilaments that expand T cells in vivo, showing efficacy against melanoma when combined with immune checkpoint blockade.

bioRxiv · Oct 14, 2022Immunology

Galectin-9 interacts with Vamp-3 to regulate cytokine secretion in dendritic cells

R. Santalla Mendez, A. Rodgers Furones, R. Classens, M. Haverdil, M. Canela Capdevila, A. van Duffelen, M. ter Beest, C. G. Spruijt, M. Vermeulen, A. B. van Spriel, L. Querol Cano

This study identifies galectin-9 as essential for cytokine trafficking in dendritic cells by interacting with Vamp-3, preventing cytokine accumulation in the Golgi and promoting secretion.

bioRxiv · May 13, 2022 · PreprintCell Biology

Dynamic regulation of CD45 by tetraspanin CD53

V.-M. E. Dunlock, A. B. Arp, E. Jansen, S. Charrin, S. J. van Deventer, M. D. Wright, L. Querol-Cano, E. Rubinstein, A. B. van Spriel

This study identifies CD53 as a stabilizer of CD45RO, enhancing TCR signaling in T cells by maintaining CD45RO surface stability and function.

bioRxiv · Nov 25, 2019Immunology

Intracellular Galectin-9 controls dendritic cell function by maintaining plasma membrane rigidity

L. Querol Cano, O. Tagit, A. van Duffelen, S. Dieltjes, S. I. Buschow, T. Niki, M. Hirashima, B. Joosten, K. van den Dries, A. Cambi, C. G. Figdor, A. B. van Spriel

This study identifies intracellular Galectin-9 as essential for maintaining plasma membrane rigidity in dendritic cells, which is critical for pathogen uptake.

bioRxiv · Aug 20, 2019Cell Biology

C-type lectin-like receptor 2 (CLEC-2)-dependent DC migration is controlled by tetraspanin CD37

C. M. de Winde, A. L. Matthews, S. van Deventer, A. van der Schaaf, N. D. Tomlinson, E. Jansen, J. A. Eble, B. Nieswandt, H. M. McGettrick, C. G. Figdor, S. E. Acton, M. G. Tomlinson, A. B. van Spriel

This study shows that CD37 stabilizes CLEC-2 membrane expression and regulates DC migration to lymph nodes via interactions with podoplanin.

bioRxiv · Dec 22, 2017Cell Biology