Author

A. Yamaguchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Assay:proteomics· 2

Frequent Co-Authors

K. Tsuchikama· 2 shared N. Zhang· 2 shared W. Xiong· 2 shared Y. Anami· 2 shared Y. Otani· 2 shared Z. An· 2 shared A. Karnkowska· 1 shared B. Dunkerly-Eyring· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBioengineering

K. Tsuchikama

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Pulsed ultrasound promotes secretion of anti-inflammatory extracellular vesicles from skeletal myotubes via elevation of intracellular calcium level

A. Yamaguchi, N. Maeshige, H. Noguchi, J. Yan, X. Ma, M. Uemura, D. Su, H. Kondo, K. Sarosiek, H. Fujino

This study shows high-intensity ultrasound increases anti-inflammatory EV secretion from skeletal myotubes by raising intracellular calcium levels, which reduces pro-inflammatory gene expression in macrophages.

bioRxiv · Jun 14, 2023Immunology

Euglenozoan kleptoplasty illuminates the early evolution of photoendosymbiosis

A. Karnkowska, N. Yubuki, M. Maruyama, A. Yamaguchi, Y. Kashiyama, T. Suzaki, P. J. Keeling, V. Hampl, B. S. Leander

This study shows that the euglenozoan Rapaza viridis uses kleptoplasts from Tetraselmis sp. for temporary photosynthesis, with evidence of horizontal gene transfer and shared mechanisms with Euglenophyceae.

bioRxiv · Nov 29, 2022 · PreprintEvolutionary Biology

Homogeneity of antibody-drug conjugates critically impacts the therapeutic efficacy in brain tumors

Y. Anami, Y. Otani, W. Xiong, S. Y. Y. Ha, A. Yamaguchi, N. Zhang, Z. An, B. Kaur, K. Tsuchikama

This study shows that homogeneous antibody-drug conjugates (ADCs) improve therapeutic efficacy in glioblastoma models compared to heterogeneous ADCs.

bioRxiv · Dec 23, 2021Bioengineering

Role of miR-181c in Diet-Induced Obesity Through Regulation of Lipid Synthesis in Liver

K. Akiyoshi, G. J. Boersma, M. D. Johnson, F. C. Velasquez, B. Dunkerly-Eyring, S. OBrien, A. Yamaguchi, C. Steenbergen, K. L. K. Tamashiro, S. Das

This study investigates miR-181c's role in diet-induced obesity by showing its regulation of lipid synthesis in liver and its impact on metabolic parameters.

bioRxiv · Aug 20, 2021Cell Biology

Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance

C. M. Yamazaki, A. Yamaguchi, Y. Anami, W. Xiong, Y. Otani, J. Lee, N. T. Ueno, N. Zhang, Z. An, K. Tsuchikama

This study develops dual-payload antibody-drug conjugates to overcome breast tumor heterogeneity and drug resistance, showing improved efficacy in a xenograft model.

bioRxiv · Dec 18, 2020Bioengineering

AIRE is induced in oral squamous cell carcinoma and promotes cancer gene expression.

K. Sakamoto, C. T. K. Nguyen, W. Sawangarun, M. Mandasari, K.-i. Morita, K. Kayamori, A. Yamaguchi

bioRxiv · Sep 6, 2019Cancer Biology

Proximity proteomics identifies cancer cell membrane cis-molecular complex as a potential cancer target

N. Kotani, A. Yamaguchi, T. Ohnishi, R. Kuwahara, T. Nakano, Y. Nakano, Y. Ida, T. Murakoshi, K. Honke

The paper identifies cancer cell membrane cis-molecular complexes (BiCATs) as potential targets using proximity proteomics and shows their utility in combination drug strategies.

bioRxiv · Oct 29, 2018Biochemistry