Author

Y. Otani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cell Biology· 1 Ecology· 1 Microbiology· 1 Zoology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Organism:non-human primate· 2 Assay:behavioral assay· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

A. Yamaguchi· 2 shared K. Tsuchikama· 2 shared N. Zhang· 2 shared W. Xiong· 2 shared Y. Anami· 2 shared Z. An· 2 shared A. K. Howe· 1 shared A. Tuuga· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBioengineering

A. Yamaguchi

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The focal adhesion protein talin is a mechanically-gated A-kinase anchoring protein (AKAP)

M. Kang, Y. Otani, Y. Guo, J. Yan, B. T. Goult, A. K. Howe

This study identifies talin1 as a mechanically-gated AKAP that binds PKA through a force-dependent interaction in focal adhesions.

Proceedings of the National Academy of Sciences · Mar 21, 2024Peer-reviewedCell Biology

Homogeneity of antibody-drug conjugates critically impacts the therapeutic efficacy in brain tumors

Y. Anami, Y. Otani, W. Xiong, S. Y. Y. Ha, A. Yamaguchi, N. Zhang, Z. An, B. Kaur, K. Tsuchikama

This study shows that homogeneous antibody-drug conjugates (ADCs) improve therapeutic efficacy in glioblastoma models compared to heterogeneous ADCs.

bioRxiv · Dec 23, 2021Bioengineering

Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance

C. M. Yamazaki, A. Yamaguchi, Y. Anami, W. Xiong, Y. Otani, J. Lee, N. T. Ueno, N. Zhang, Z. An, K. Tsuchikama

This study develops dual-payload antibody-drug conjugates to overcome breast tumor heterogeneity and drug resistance, showing improved efficacy in a xenograft model.

bioRxiv · Dec 18, 2020Bioengineering

Individual identification of Japanese macaques (Macaca fuscata) using a face recognition system and a limited number of learning images

Y. Otani, H. Ogawa

This paper develops a face recognition system for Japanese macaques using a limited number of learning images to improve individual identification in field research.

bioRxiv · Jul 12, 2020Zoology

Factors influencing riverine utilization patterns in two sympatric macaques

Y. Otani, H. Bernard, A. Wong, J. Tangah, A. Tuuga, G. Hanya, I. Matsuda

The paper examines factors influencing riverine utilization in two sympatric macaque species and compares them with proboscis monkeys, finding that food availability and predation pressure drive their riverine behavior.

bioRxiv · Jun 11, 2020Ecology

Comparison of prokaryotic communities among fields exhibiting different disinfestation effects by anaerobic soil disinfestation

C. G. Lee, T. Iida, E. Matusda, K. Yoshida, M. Kawabe, M. Maeda, H. Watanabe, Y. Muramoto, Y. Otani, K. Nakaho, M. Ohkuma

The paper compares prokaryotic communities in soils with different disinfestation effects after anaerobic soil disinfestation, finding specific microbial changes associated with effective disinfestation.

bioRxiv · Jul 23, 2019 · PreprintMicrobiology