Author

A. Yasgar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Organism:human· 1

Frequent Co-Authors

A. Simeonov· 3 shared A. V. Zakharov· 2 shared A. G. Godfrey· 1 shared B. Baljinnyam· 1 shared C. Klumpp-Thomas· 1 shared C. Kreisbeck· 1 shared C. Lynch· 1 shared C. McKnight· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersPharmacology & Toxicology

A. Simeonov

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Author profile →

3 papers

Recent·Most cited

Quantitative bioactivity signatures of dietary supplements and natural products

A. Yasgar, D. Bougie, C. McKnight, M. Miller, T. Peryea, M. Xia, P. Shah, X. Xu, P. Shinn, M. Itkin, C. Lynch, A. V. Zakharov, R. Eastman, J. Kouznetsova, D. Ngan, , A. Simeonov

The paper screens dietary supplements and natural products for bioactivity using in vitro assays and predicts their mechanisms of action by comparing activity profiles with approved drugs.

bioRxiv · Sep 14, 2022Pharmacology & Toxicology

Cross-platform Bayesian optimization system for autonomous biological assay development

S. Elder, C. Klumpp-Thomas, A. Yasgar, J. Travers, S. Frebert, K. M. Wilson, A. V. Zakharov, J. L. Dahlin, C. Kreisbeck, D. Sheberla, G. S. Sittampalam, A. G. Godfrey, A. Simeonov, S. Michael

This paper develops a cross-platform Bayesian optimization system to accelerate biological assay development, reducing costs and time compared to brute force methods.

bioRxiv · Jun 23, 2021Biochemistry

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

J. M. Rohde, K. R. Brimacombe, L. Liu, M. E. Pacold, A. Yasgar, D. M. Cheff, T. D. Lee, G. Rai, B. Baljinnyam, Z. Li, A. Simeonov, M. D. Hall, M. Shen, D. M. Sabatini, M. B. Boxer

The paper develops a biochemical assay to screen for PHGDH inhibitors, identifies piperazine-1-thiourea compounds, and evaluates their biological impact on serine metabolism in cancer cells.

Bioorganic & Medicinal Chemistry · May 1, 2018Peer-reviewedCancer Biology