Author

D. M. Cheff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:batch correction / integration· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

M. D. Hall· 4 shared T. D. Lee· 4 shared A. Simeonov· 3 shared M. Shen· 3 shared C. Klumpp-Thomas· 2 shared J. M. Rohde· 2 shared K. R. Brimacombe· 2 shared M. B. Boxer· 2 shared

Activity by Year

2017-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersCell Biology

M. D. Hall

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Author profile →

4 papers

Recent·Most cited

Keeping it clean: the cell culture quality control experience at the National Center for Advancing Translational Sciences

J. S. Roth, T. D. Lee, D. M. Cheff, M. L. Gosztyla, R. Asawa, C. Danchik, S. Michael, A. Simeonov, C. Klumpp-Thomas, K. Wilson, M. D. Hall

The paper describes NCATS's implementation of mycoplasma and STR testing to improve cell line quality, reducing contamination and misidentification in translational research.

bioRxiv · Oct 9, 2019Cell Biology

Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening

O. W. Lee, S. M. Austin, M. R. Gamma, D. M. Cheff, T. D. Lee, K. M. Wilson, J. M. Johnson, J. C. Travers, J. C. Braisted, R. Guha, C. Klumpp-Thomas, M. Shen, M. D. Hall

The paper profiles cytotoxicity of over 100,000 compounds across normal and cancer cell lines to identify cytotoxic compounds and improve screening efficiency.

bioRxiv · Feb 5, 2019Cell Biology

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

J. M. Rohde, K. R. Brimacombe, L. Liu, M. E. Pacold, A. Yasgar, D. M. Cheff, T. D. Lee, G. Rai, B. Baljinnyam, Z. Li, A. Simeonov, M. D. Hall, M. Shen, D. M. Sabatini, M. B. Boxer

The paper develops a biochemical assay to screen for PHGDH inhibitors, identifies piperazine-1-thiourea compounds, and evaluates their biological impact on serine metabolism in cancer cells.

Bioorganic & Medicinal Chemistry · May 1, 2018Peer-reviewedCancer Biology

Assessing Inhibitors Of Mutant Isocitrate Dehydrogenase Using A Suite Of Pre-Clinical Discovery Assays

D. J. Urban, N. J. Martinez, M. I. Davis, K. R. Brimacombe, D. M. Cheff, T. D. Lee, M. J. Henderson, S. A. Titus, R. Pragani, J. M. Rohde, Y. Wang, S. Karavadhi, P. Shah, O. W. Lee, A. Wang, , M. D. Hall

The paper evaluates inhibitors of mutant IDH1 and IDH2 using biochemical and cell-based assays to identify effective compounds for cancer therapy.

bioRxiv · Apr 7, 2017Cancer Biology