Dirty mice better recapitulate key features of mRNA vaccine immunogenicity observed in humans
Beatriz Praena, Frances K. Shepherd, Cera A. McDonald, Devyani Joshi, Sneh Lata Gupta, Madison L Ellis, Lilin Lai, Alberto Moreno, Shanley N. Roach, Mark J. Pierson, Adam J. Gilbertsen, Carl W. Davis, Mehul S. Suthar, Jens Wrammert, Ryan Andrew Langlois
This study shows that dirty mice, with broad microbial exposure, better model human immune responses to SARS-CoV-2 mRNA vaccines, showing reduced antibody titers and faster waning compared to SPF mice.
mBio · Jul 6, 2026Peer-reviewedImmunology