Author

Alejandro García López

University Medical Center Groningen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Bert van de KooijiD· 1 shared Dan Ruan· 1 shared Femke J. BakkeriD· 1 shared Frank N. MoliD· 1 shared H. Rudolf de BoeriD· 1 shared Harry M. WarneriD· 1 shared Lauren de HaaniD· 1 shared Marcel A.T.M. van VugtiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Bert van de KooijORCID

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1 paper

Recent·Most cited

CIP2A is required for mitotic recruitment of the SLX1/XPF/MUS81 tri-nuclease complex to replication stress-induced DNA lesions to maintain genome integrity

Lauren de Haan, Sietse J. Dijt, Alejandro García López, Dan Ruan, Femke J. Bakker, Marieke Everts, Harry M. Warner, Frank N. Mol, H. Rudolf de Boer, Pim J. Huis in ’t Veld, Bert van de Kooij, Rifka Vlijm, Marcel A.T.M. van Vugt

This study shows that CIP2A-TOPBP1 recruits the SMX tri-nuclease complex to resolve mitotic DNA lesions, ensuring genome integrity and survival of BRCA2-deficient cells.

bioRxiv · Apr 3, 2025 · PreprintCell Biology