Author
University Medical Center GroningenORCID 0000-0002-6078-8333Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Lauren de Haan, Rebecca Schneeweiss, Marco Barazas…·Pim J. Huis in ’t Veld
This study shows that CIP2A tetramerization is essential for mitotic DNA repair and survival of BRCA1/2 mutant cancer cells.
Rinskje B. Tjeerdsma, Timothy F. Ng, Maurits Roorda…·Marcel A.T.M. van Vugt
This study shows WEE1 inhibitors trigger the integrated stress response via GCN2 activation, leading to translational shutdown, which can be mitigated by low-dose or combination treatments.
Lauren de Haan, Sietse J. Dijt, Alejandro García López…·Marcel A.T.M. van Vugt
This study shows that CIP2A-TOPBP1 recruits the SMX tri-nuclease complex to resolve mitotic DNA lesions, ensuring genome integrity and survival of BRCA2-deficient cells.