Author

Dan Ruan

University Medical Center GroningenPrimary ORCID profile (0000-0003-3400-7684 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Dan RuaniD2 papers · University of California, Los Angeles

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alejandro García López· 1 shared Bert van de KooijiD· 1 shared Femke J. BakkeriD· 1 shared Frank N. MoliD· 1 shared H. Rudolf de BoeriD· 1 shared Harry M. WarneriD· 1 shared Lauren de HaaniD· 1 shared Marcel A.T.M. van VugtiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Alejandro García López

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1 paper

Recent·Most cited

CIP2A is required for mitotic recruitment of the SLX1/XPF/MUS81 tri-nuclease complex to replication stress-induced DNA lesions to maintain genome integrity

Lauren de Haan, Sietse J. Dijt, Alejandro García López, Dan Ruan, Femke J. Bakker, Marieke Everts, Harry M. Warner, Frank N. Mol, H. Rudolf de Boer, Pim J. Huis in ’t Veld, Bert van de Kooij, Rifka Vlijm, Marcel A.T.M. van Vugt

This study shows that CIP2A-TOPBP1 recruits the SMX tri-nuclease complex to resolve mitotic DNA lesions, ensuring genome integrity and survival of BRCA2-deficient cells.

bioRxiv · Apr 3, 2025 · PreprintCell Biology