Author

Aleksandr Kralovec

Morgridge Institute for Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Assay:imaging· 1 Assay:metabolomics· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

Anna Huttenlocher AiD· 2 shared James A. VotavaiD· 2 shared Jing FaniD· 2 shared Melissa C. SkalaiD· 2 shared Rupsa DattaiD· 2 shared Amani A. GilletteiD· 1 shared Carlos Mellado FritziD· 1 shared Emily C. BrittiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

Anna Huttenlocher AORCID

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2 papers

Recent·Most cited

Single cell autofluorescence imaging reveals immediate metabolic shifts of neutrophils with activation across biological systems

Rupsa Datta, Veronika Miskolci, Gina M. Gallego-López, Emily C. Britt, Amani A. Gillette, Aleksandr Kralovec, Morgan A. Giese, Tongcheng Qian, James A. Votava, Wenxuan Zhao, Jing Fan, Anna Huttenlocher, Melissa C. Skala

This study uses optical metabolic imaging to show neutrophils rapidly shift to a reduced redox state upon activation, with heterogeneous responses across cells and donors.

Frontiers in Immunology · Aug 7, 2025Peer-reviewedImmunology

Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response

Jorgo Lika, James A. Votava, Rupsa Datta, Carlos Mellado Fritz, Aleksandr Kralovec, Frances M. Smith, Anna Huttenlocher A, Melissa C. Skala, Jing Fan

This study shows that mature neutrophils can rapidly reactivate mitochondrial metabolism in response to stimuli, impacting their function and suggesting therapeutic potential for mitochondrial pyruvate carrier inhibitors.

Frontiers in Immunology · Apr 28, 2025Peer-reviewedImmunology