Author

Frances M. Smith

University of Wisconsin–Madison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:metabolomics· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Anna Huttenlocher AiD· 2 shared James A. VotavaiD· 2 shared Jing FaniD· 2 shared Melissa C. SkalaiD· 2 shared Rupsa DattaiD· 2 shared Aleksandr Kralovec· 1 shared Andrew S. WagneriD· 1 shared Carlos Mellado FritziD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

Anna Huttenlocher AORCID

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2 papers

Recent·Most cited

Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response

Jorgo Lika, James A. Votava, Rupsa Datta, Carlos Mellado Fritz, Aleksandr Kralovec, Frances M. Smith, Anna Huttenlocher A, Melissa C. Skala, Jing Fan

This study shows that mature neutrophils can rapidly reactivate mitochondrial metabolism in response to stimuli, impacting their function and suggesting therapeutic potential for mitochondrial pyruvate carrier inhibitors.

Frontiers in Immunology · Apr 28, 2025Peer-reviewedImmunology

GATA1-deficient human pluripotent stem cells generate neutrophils with improved antifungal immunity that is mediated by the integrin CD18

Andrew S. Wagner, Frances M. Smith, David A. Bennin, James A. Votava, Rupsa Datta, Morgan A. Giese, Wenxuan Zhao, Melissa C. Skala, Jing Fan, Nancy P. Keller, Anna Huttenlocher A

This study shows that GATA1-deficient iPSC-derived neutrophils have enhanced antifungal activity against Aspergillus fumigatus, mediated by CD18 integrin.

PLoS Pathogens · Feb 3, 2025Peer-reviewedMicrobiology