David Dombrowicz

Rev-erb-alpha inhibits vascular calcification by repressing osteogenic reprogramming in atherosclerosis

This study identifies Rev-erb-alpha as a repressor of vascular calcification by inhibiting osteogenic reprogramming of vascular smooth muscle cells in atherosclerosis.

Accurate and memory-efficient cell type annotation from multimodal single-cell RNA and protein data

pyODIN improves cell type annotation by integrating RNA and protein data, achieving higher accuracy and resolving finer cell subtypes than existing methods.

CSF1R regulates monocyte subset differentiation and intracellular metabolism.

This study shows that CSF1R regulates monocyte differentiation and metabolism, with its blockade reducing Ly6Clow monocytes and affecting subset diversity through the hexosamine biosynthetic pathway.

PI3Kδ Bridges Microbial Surveillance with Antigen Presentation to Reinforce Intestinal Immunity

This study shows PI3Kδ is critical for dendritic cell function in intestinal immunity by linking microbial sensing to antigen presentation and T-cell activation.

CD226+ macrophages arise from MDP-derived monocytes and regulate lipid metabolism.

The paper identifies CD226high macrophages derived from MDP monocytes as a new myeloid cell type involved in lipid metabolism regulation across tissues.

CytoBatchNorm: an R package with graphical interface for batch effects correction of cytometry data

The HDAC inhibitor trichostatin A impairs pancreatic β-cell function through an epigenome-wide reprogramming

This study shows that HDAC inhibition by trichostatin A disrupts β-cell function and identity through epigenome-wide remodeling in both mouse and human β-cell models.

A time- and space-resolved nuclear receptor atlas in mouse liver

This paper maps nuclear receptor expression in mouse liver across time and space using single-cell RNAseq data.