Stoyan Ivanov

CSF1R regulates monocyte subset differentiation and intracellular metabolism.

This study shows that CSF1R regulates monocyte differentiation and metabolism, with its blockade reducing Ly6Clow monocytes and affecting subset diversity through the hexosamine biosynthetic pathway.

Depletion and replacement of tissue resident macrophages in mice with germ-line deletion of a conserved enhancer in the Csf1r locus.

This study shows that mice with a germ-line deletion of a Csf1r enhancer lack specific macrophages but maintain normal physiology and can be replenished by donor cells.

Adrenal Gland Macrophage-derived TGF-β Governs Vascular Permeability to Drive Monocyte Recruitment during Stress

p16High immune cell - controlled disease tolerance as a broad defense and healthspan extending strategy

This study identifies p16High immune cells as critical for disease tolerance, showing they enhance survival in various conditions and extend healthspan by maintaining low adenosine levels.

Unveiling a unique macrophage population in exocrine glands sustained by ILC2-derived GM-CSF

The paper identifies a novel macrophage-like population in exocrine glands sustained by ILC2-derived GM-CSF, showing conservation across species.

Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages (LAMs)

This study identifies conserved and tissue-specific transcriptional profiles of lipid-associated macrophages (LAMs) across species and inflammatory conditions using single-cell RNA sequencing.

MACanalyzeR: scRNA-seq Analysis Tool Reveals PPARγHI Lipid-Associated Macrophages Facilitate Thermogenic Expansion in BAT

The paper introduces MACanalyzeR, a scRNA-seq tool, to identify PPARγ-high lipid-associated macrophages in BAT that support thermogenic expansion.

The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ- dependent but monocyte-independent process.

The paper identifies CSF1 and TGFβ as key signals for synovial lining macrophage development in mice, which occurs postnatally and is monocyte-independent.

CD226+ macrophages arise from MDP-derived monocytes and regulate lipid metabolism.

The paper identifies CD226high macrophages derived from MDP monocytes as a new myeloid cell type involved in lipid metabolism regulation across tissues.