Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks
Quan Jiang, Ling-Xiao Shao, Shenqin Yao, Neil K. Savalia, Amelia D. Gilbert, Pasha A. Davoudian, Jack D. Nothnagel, Guilian Tian, Jacky Tin Shing Hung, H. M. Lai, Kevin Thomas Beier, Hongkui Zeng, Alex C. Kwan
This study shows psilocybin alters large-scale cortical network connectivity in mice by strengthening inputs from perceptual and medial regions and weakening cortico-cortical loops, dependent on drug-evoked spiking activity.
Cell · Dec 5, 2025Peer-reviewedNeuroscience