PfK13-associated artemisinin resistance slows drug activation and enhances antioxidant defence, which can be overcome with sulforaphane.
Ghizal Siddiqui, Carlo Giannangelo, Natalie A. Counihan, Yudong Zhou, Annie Roys, Amanda De Paoli, Bethany M. Anderson, Matthew P. Challis, Lee Ming Yeoh, Stuart A. Ralph, Laura E. Edgington‐Mitchell, Tania F. de Koning‐Ward, Darren J. Creek
This study identifies PfK13 mutations as drivers of artemisinin resistance by enhancing antioxidant defenses, which can be counteracted by sulforaphane.
bioRxiv · Oct 5, 2025 · PreprintMicrobiology