Ghizal Siddiqui

MMV687794 blocks Plasmodium falciparum invasion of red blood cells by targeting a Surface-associated Lipid-Interacting Rhoptry Protein, PfSLIRP

This study identifies MMV687794 as an inhibitor of Plasmodium falciparum RBC invasion by targeting PfSLIRP, a rhoptry protein involved in lipid metabolism and vacuole formation.

Validation of Solvent Proteome Profiling for Antimalarial Drug Target Deconvolution

This study validates solvent proteome profiling (SPP) as a method to identify antimalarial drug targets in Plasmodium falciparum by detecting ligand-induced protein stability changes.

PfK13-associated artemisinin resistance slows drug activation and enhances antioxidant defence, which can be overcome with sulforaphane.

This study identifies PfK13 mutations as drivers of artemisinin resistance by enhancing antioxidant defenses, which can be counteracted by sulforaphane.

Deconvolution of the on-target activity of plasmepsin V peptidomimetics in P. falciparum parasites

This study investigates the on-target activity of plasmepsin V peptidomimetics in Plasmodium falciparum by combining chemoproteomic methods and genetic validation.