Author

Amanda De Paoli

Monash UniversityORCID 0000-0002-7617-9655Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:plant (other)· 1 Assay:proteomics· 1

Frequent Co-Authors

Annie Roys· 1 shared Bethany M. AndersoniD· 1 shared Carlo GiannangeloiD· 1 shared Darren J. CreekiD· 1 shared Ghizal SiddiquiiD· 1 shared Laura E. Edgington‐MitchelliD· 1 shared Lee Ming YeohiD· 1 shared Matthew P. ChallisiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMicrobiology

Annie Roys

Mutual co-authors in cluster

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1 paper

Recent·Most cited

PfK13-associated artemisinin resistance slows drug activation and enhances antioxidant defence, which can be overcome with sulforaphane.

Ghizal Siddiqui, Carlo Giannangelo, Natalie A. Counihan, Yudong Zhou, Annie Roys, Amanda De Paoli, Bethany M. Anderson, Matthew P. Challis, Lee Ming Yeoh, Stuart A. Ralph, Laura E. Edgington‐Mitchell, Tania F. de Koning‐Ward, Darren J. Creek

This study identifies PfK13 mutations as drivers of artemisinin resistance by enhancing antioxidant defenses, which can be counteracted by sulforaphane.

bioRxiv · Oct 5, 2025 · PreprintMicrobiology