Author

Peng Gao

Northwestern UniversityORCID 0000-0002-9991-6064Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Peng Gao8 papers · Agriculture and Agri-Food Canada

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Abul Bashar Mir Md. Khademul IslamiD· 1 shared Austin T. Klein· 1 shared Curtis W. McCloskeyiD· 1 shared Daniel James McGrailiD· 1 shared Elizaveta V. BenevolenskayaiD· 1 shared Flávio Romero PalmaiD· 1 shared Gannon CottoneiD· 1 shared Hardik ShahiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Abul Bashar Mir Md. Khademul IslamORCID

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2 papers

Recent·Most cited

Succinate dehydrogenase activity supports de novo purine synthesis

Mushtaq Ahmad Nengroo, Austin T. Klein, Heather S. Carr, Olivia Vidal-Cruchez, Umakant Sahu, Daniel James McGrail, Nidhi Sahni, Niklas B. Thompson, Peter Allen Faull, Peng Gao, John M. Asara, Hardik Shah, Marc L. Mendillo, Issam Ben‐Sahra

This study shows that succinate dehydrogenase supports de novo purine synthesis in cancer cells, and its inhibition reduces proliferation by impairing purine biosynthesis and inducing a compensatory salvage pathway.

Molecular Cell · Oct 28, 2025Peer-reviewedBiochemistry

Metabolic shift to serine pathway induced by lipids confers oncogenic properties in non-transformed breast cells

Mariana Bustamante Eduardo, Gannon Cottone, Curtis W. McCloskey, Shiyu Liu, Flávio Romero Palma, María Paula Zappia, Abul Bashar Mir Md. Khademul Islam, Peng Gao, Joel Setya, Saya Dennis, Hongyu Gao, Qian Zhang, Xiaoling Xuei, Yuan Luo, Jason W. Locasale, , Susan E. Clare

The paper shows that lipid metabolism, specifically through OA, shifts metabolic pathways in breast cells, increasing SAM and 2-HG, which contribute to oncogenic properties and epigenetic changes.

Science Advances · Mar 21, 2025Peer-reviewedCancer Biology