Author

Umakant Sahu

Northwestern UniversityORCID 0000-0002-7269-4430Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Issam Ben‐SahraiD· 2 shared Aditi GuptaiD· 1 shared Arthur GouraudiD· 1 shared Austin T. Klein· 1 shared Clément MolinaiD· 1 shared Daniel James McGrailiD· 1 shared Gilles PagèsiD· 1 shared Hardik ShahiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

Issam Ben‐SahraORCID

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3 papers

Recent·Most cited

Succinate dehydrogenase activity supports de novo purine synthesis

Mushtaq Ahmad Nengroo, Austin T. Klein, Heather S. Carr, Olivia Vidal-Cruchez, Umakant Sahu, Daniel James McGrail, Nidhi Sahni, Niklas B. Thompson, Peter Allen Faull, Peng Gao, John M. Asara, Hardik Shah, Marc L. Mendillo, Issam Ben‐Sahra

This study shows that succinate dehydrogenase supports de novo purine synthesis in cancer cells, and its inhibition reduces proliferation by impairing purine biosynthesis and inducing a compensatory salvage pathway.

Molecular Cell · Oct 28, 2025Peer-reviewedBiochemistry

Exploiting De Novo Serine Synthesis as a Metabolic Vulnerability to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma

Manon Teisseire, Umakant Sahu, Julien Parola, Meng‐Chen Tsai, Valérie Vial, Jérôme Durivault, Renaud Grépin, Yann Cormerais, Clément Molina, Arthur Gouraud, Gilles Pagès, Issam Ben‐Sahra, Sandy Giuliano

This study identifies serine synthesis as a metabolic vulnerability in sunitinib-resistant renal cell carcinoma, showing that inhibiting key enzymes enhances drug sensitivity.

Cancer Research · Mar 3, 2025Peer-reviewedCancer Biology

Function and regulation of an aldehyde dehydrogenase essential for ethanol and methanol metabolism of the yeast,Komagataella phaffii

Aditi Gupta, Kamisetty Krishna Rao, Umakant Sahu, Pundi Narasimhan Rangarajan

This study identifies Mxr1p as a key regulator of ALD-A transcription and shows post-transcriptional regulation of AOX during methanol metabolism in K. phaffii.

Journal of Biological Chemistry · Sep 27, 2021Peer-reviewedMolecular Biology