Author

P. A. MacAry

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Organism:virus· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

K. Purushotorman· 3 shared X. Qian· 2 shared A. D. T. Barrett· 1 shared A. Dinan· 1 shared A. P. C. Lim· 1 shared A. Trelles· 1 shared A. Weimann· 1 shared A. Y.-Y. Yeoh· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersImmunology

K. Purushotorman

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Single shot dendritic cell targeting SARS-CoV-2 vaccine candidate induces broad and durable systemic and mucosal immune responses

N. Y. Z. Cheang, P. S. Tan, K. Purushotorman, W. C. Yap, B. Y. L. Chua, K. S. Tan, K. M. Tullett, A. Y.-Y. Yeoh, C. Q. H. Tan, X. Qian, D. J. W. Tay, I. Caminschi, Y. J. Tan, P. A. MacAry, C. W. Tan, , S. Alonso

This study evaluates a SARS-CoV-2 vaccine candidate that targets dendritic cells, showing durable systemic and mucosal immune responses against multiple variants.

bioRxiv · Feb 21, 2023 · PreprintImmunology

Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis

C. Maserumule, C. Passemar, O. Oh, K. Hegyi, K. Brown, A. Weimann, A. Dinan, S. Davila, C. Klapholz, J. Bryant, D. Verma, J. Gadwa, S. Krishnananthasivam, K. Vongtongsalee, E. Kendall, , R. A. Floto

The paper identifies TLR8 as a key regulator of intracellular killing of Mtb, showing that phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis and reveals a druggable pathway for host-directed therapy.

bioRxiv · Jun 14, 2022Immunology

Mapping the allosteric effects that define functional activity of SARS-CoV-2 specific antibodies

N. K. Tulsian, P. V. Raghuvamsi, X. Qian, G. Yue, B. D/O Shunmuganathan, F. Samsudin, Y. H. Wong, L. Jianqing, K. Purushotorman, M. K. McQueen, B. Wang, J. Lescar, C.-I. Wang, G. Anand, P. J. Bond, P. A. MacAry

This study identifies site-specific allosteric effects in SARS-CoV-2 Spike protein induced by different neutralizing antibodies, revealing dynamic features that distinguish weak from strong neutralizers.

bioRxiv · Dec 27, 2021 · PreprintBiochemistry

The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody

C. E. Z. Chan, S. G. K. Seah, D. H. Chye, S. Massey, M. Torres, A. P. C. Lim, S. K. K. Wong, J. J. Y. Neo, P. S. Wong, J. H. Lim, G. S. L. Loh, D. L. Wang, J. D. Boyd-Kirkup, S. Guan, D. Thakkar, , B. J. Hanson

The paper identifies SC31, a potent SARS-CoV-2 neutralizing antibody, and shows that its Fc-mediated effector functions are critical for its therapeutic efficacy in vivo.

bioRxiv · Oct 26, 2020Microbiology

Characterization and establishment of a novel EBV strain simultaneously associated with nasopharyngeal carcinoma and B-cell lymphoma

F. Yu, N. Syn, Y. Lu, Q. Y. Chong, J. Lai, W. J. Tan, B. C. Goh, P. A. MacAry, L. Wang, K. S. Loh

The paper characterizes a novel EBV strain, Yu103, associated with both nasopharyngeal carcinoma and B-cell lymphoma, showing its dual tropism and unique genomic features.

bioRxiv · Mar 26, 2020Cancer Biology