Author

B. D. Grant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5

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Assay:proteomics· 5 Organism:C. elegans· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Approach:genetic perturbation / CRISPR· 3 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Norris· 2 shared G. Bai· 2 shared A. J. Smart· 1 shared B. B. Joseph· 1 shared C. McManus· 1 shared D. Fay· 1 shared D. H. Hall· 1 shared I. Melentijevic· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCell Biology

A. Norris

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5 papers

Recent·Most cited

A Conserved Requirement for RME-8/DNAJC13 in Neuronal Autolysosome Reformation

S. B. Swords, N. Jia, A. Norris, J. Modi, Q. Cai, B. D. Grant

This study identifies RME-8/DNAJC13 as a conserved factor required for autolysosome reformation in neurons, linking it to autophagic flux and neurodegenerative disease mechanisms.

bioRxiv · Feb 27, 2023 · PreprintCell Biology

Active zone protein SYD-2/Liprin-α acts downstream of LRK-1/LRRK2 to regulate polarized trafficking of synaptic vesicle precursors through clathrin adaptor protein complexes

S. S. P. Nadiminti, S. B. Dixit, N. Ratnakaran, S. Hegde, S. Swords, B. D. Grant, S. P. Koushika

This study identifies SYD-2/Liprin-α as a downstream effector of LRK-1/LRRK2 that regulates polarized trafficking of synaptic vesicle precursors through AP-3 and AP-1 complexes in C. elegans neurons.

bioRxiv · Feb 26, 2023 · PreprintCell Biology

Conserved NIMA kinases regulate multiple steps of endocytic trafficking

B. B. Joseph, N. Naslavsky, S. Binti, S. Conquest, L. Robison, G. Bai, B. D. Grant, S. Caplan, D. Fay

This study shows that NIMA kinases regulate endocytic trafficking in worms and humans, affecting endosome morphology and cargo sorting, with implications for disease.

bioRxiv · Dec 22, 2022Cell Biology

Mutagenesis and structural modeling implicate RME-8 IWN domains as conformational control points

A. Norris, C. McManus, R. Ying, S. Wang, B. D. Grant

The paper identifies IWN domains in RME-8 as conformational control points that regulate DNAJ domain exposure and function through interactions with SNX-1.

PLOS Genetics · Oct 24, 2022Peer-reviewedCell Biology

Intermediate Filaments Associate with Aggresome-like Structures in Proteostressed C. elegans Neurons and Influence Large Vesicle Extrusions as Exophers

M. L. Arnold, J. F. Cooper, R. Androwski, S. Ardeshna, I. Melentijevic, A. J. Smart, R. J. Guasp, K. C. Nguyen, G. Bai, D. H. Hall, B. D. Grant, M. Driscoll

This study shows that intermediate filaments in C. elegans neurons form aggresome-like structures under proteostress and influence exopher production for aggregate removal.

bioRxiv · Aug 3, 2022 · PreprintCell Biology